Browsing by Author "Ramapuram, Jayachandra"

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Application of 3D Printing in Personalized Drug Delivery Devices and Dosage Forms

Poudel, Ishwor (2023-11-03) ETD File Embargoed

The evolution of 3D Printing (3DP) and its applications in various disciplines, including healthcare, in the past few years has been exemplary. The gradual shift from the conventional “one size fits all” concept to ...

Application of Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) for Lipid-based Nanomedicine Development

Nie, Ben (2017-04-25)

Secretory phospholipase A2 (sPLA2) are increased in various cancers. The lipid specificity and reactivity of sPLA2 and its ability to interact with PLA2 receptors (PLA2R) are potential targets for development of liposome ...

Clinical Pharmacokinetic Analysis and Modeling of Tranexamic Acid in Dogs

Almoslem, Mohammed (2018-05-30)

Tranexamic Acid (TXA) is an FDA approved drug for hemophilia patients undergoing dental extractions and women experiencing heavy bleeding during menstrual periods. It is also used to stop bleeding and decrease risk of ...

Comparative Stability of Aspirin in CSP Technologies Active-VialTM and Owens- Illinois L-8 Prescription Vials

Tata, Atresh (2007-05-15)

The traditional way of drug packaging includes a desiccant pouch along with the drug. The desiccant in the vial helps in preventing the drug degradation due to moisture in surrounding environment. This traditional packaging ...

Determine the Anticancer Activity and Mechanism of Overcoming Drug Resistance by Cu(DDC)2 NPs in Prostate Cancers

Wang, Junwei (2021-07-14) ETD File Embargoed

Copper diethyldithiocarbamate [Cu(DDC)2] complex formed by disulfiram (DSF) and copper ions is a promising therapeutic agent for cancer treatment. However, the poor aqueous solubility of Cu(DDC)2 limited its clinical ...

Development of micelle delivery systems for cancer therapy

Wang, Qi (2023-12-08) ETD File Embargoed

Polymeric micelles have been investigated as nanomedicines for cancer treatment. They can target specific tissues, prolong circulation, and reduce side effects. These features make them a promising delivery system for ...

Drug Delivery Devices for Cancer and Posterior Eye

Alrbyawi, Hamad (2019-11-22) ETD File Embargoed

Skin cancer is by far the most common of all cancers. Among all types of skin cancer, malignant melanoma causes most of the deaths. Likewise, breast cancer is the most common cancer in women after skin cancer and the second ...

Effect of Extended Exposure Topotecan on Drug Resistance Using a Novel 3D Spheroidal Model of Castrate-Resistant Prostate Cancer

Davis, Joshua (2023-04-24)

Cancer consistently commands the highest number of therapeutic drug approvals each year, however, this has yet to yield significant clinical benefits for metastatic disease. Instead, most drugs are likely to increase ...

Elucidate the Neuro-Pharmacodynamic Actions of 3-Hydroxypterostilbene

Kadannagari, Surekha (2022-11-29)

Pterostilbene (dimethyl ether analog of resveratrol) is a metabolically stable natural bioactive and has exhibited substantial pharmacological activities. 3-Hydroxypterostilbene is a natural pterostilbene analog and an ...

Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling

Darakjian, Lucy (2020-05-14)

In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...

Formulation of Phytochemicals in Lipid-Based Nanoparticles for Melanoma Treatment

Al Saqr, Ahmed (2019-04-25)

Melanoma is one of the most common and aggressive types of cancer with high mortality. Current treatment is ineffective in preventing relapse of cancer. It also suffers from serious systemic side effects because of the ...

Formulation of Water Insoluble Drugs for Ocular Delivery

Shelley, Haley (2018-07-24)

Cyclodextrins are unique cyclic molecules with a hydrophobic interior and hydrophilic exterior that can be used to solubilize, stabilize and enhance targetability of the encapsulated molecules. Chapter 1 will discuss uses ...

Inclusion Complexation of Gefitinib with Cyclodextrins

Lee, Yann-Huei (2008-08-15)

Gefitinib, a very slightly soluble new drug, is used in the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in patients who have previously received chemotherapy. This study examined the ...

Investigation of Mass Transfer Phenomena in Supercritical Antisolvent Precipitation Processes

Chinnawar, Rajeshwar (2015-08-04)

This dissertation involves a detailed discussion of the production of organic and polymeric microparticles of controllable size and size distribution for several applications including certain pharmaceutical formulations. ...

Microneedles Assisted Iontophoretic Transdermal Delivery of Drugs

Pawar, Kasturi (2013-11-01)

Topical/transdermal delivery offers an attractive alternative to oral and parenteral delivery in terms of non-invasiveness, administration and termination of dose and drug stability etc. However, the excellent barrier ...

Nanoparticle and Gel Based Formulations for Enhanced Drug Delivery

Aldawsari, Mohammed (2017-11-28)

Nanogel and hydrogel formulations have shown promising advantages for topical and trans-mucosal routes of administration. The nanoparticle drug within the gel matrix showed significant enhancement in the permeation of drugs ...

Promethazine Orally Disintegrating Tablet

Graben, Roger (2006-05-15)

Orally Disintegrating Tablets (ODTs) which disintegrate rapidly (< one minute) in the mouth and do not require water for administration have become a very popular dosage form. Current methods of manufacturing ODTs are ...

Short-Chain Ceramides for Enhancing Cytotoxicity of Liposome-Encapsulated Doxorubicin Toward Human Breast Cancer (MDA-MB-231) and Prostate Cancer (PC-3) Cells

Alrbyawi, Hamad (2016-08-01)

Co-delivery of short chain ceramide, C6-Ceramide (C6-Cer) and C8-Ceramide (C8-Cer) and doxorubicin (DOX) using a liposomal system in MDA-MB-231 breast cancer and PC3 prostate cancer cell lines for synergistic cytotoxic ...

Three-dimensional Printing of Drug-eluting Implants and Orodispersible Films

Annaji, Manjusha (2023-09-25) ETD File Embargoed

Three-dimensional (3D) printing is a rapidly emerging additive manufacturing technology utilized to quickly fabricate customized dosage forms with complex geometrical designs. Due to its flexibility in adjusting the dose, ...

Transdermal Iontophoretic Delivery of Selegiline and Prochlorperazine

Xiao, Jin (2010-12-07)

Transdermal iontophoretic delivery of selegiline hydrochloride (SH) across dermatomed human skin was studied. SH was stable under the influence of electrical field. Increase in drug concentration from 1 to 20 mg/ml, increased ...