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Modulation of Human PXR by Novel KRAS-G12C Inhibitors: Implications in Cancer Therapy
Salamat, Julia (2023-08-01) ETD File Embargoed
The nuclear receptor human pregnane xenobiotic receptor (hPXR) is a transcription factor responsible for the regulation of key drug metabolism enzymes (DMEs) and drug efflux pumps (DEPs), including cytochrome p450 3A4 ...