Browsing by Author "Schneller, Stewart"

Now showing items 1-11 of 11

8-Alkyl Adenines and Their Nucleoside Derivatives

Abouelghit, Maha (2011-07-28)

S-adenosylhomocysteine hydrolase has become an important target in the design of antiviral drugs. It is the only known enzyme in eukaryotes that is responsible for the catabolism of S-adenosylhomocysteine into adenosine ...

Carbocyclic C-Nucleosides Derived from Formycin

He, Mingzhu (2008-12-15)

Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. Some modified nucleosides have become major therapeutic agents for the treatment ...

Design and Synthesis of 3-Deazaaristeromycin Derivatives

Chen, Chun (2010-12-07)

Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. The carbocyclic nucleosides aristeromycin and neplanocin A are two examples that ...

Design and Synthesis of AdoHcy Hydrolase Inhibitors as a Source of Antiviral Agents

Liu, Chong (2008-05-15)

The significant antiviral properties of the carbocyclic nucleosides aristeromycin and neplanocin A have been attributed to inhibition of AdoHcy hydrolase, which in turn affects viral mRNA capping methylation. However, their ...

Enantioselective synthesis of 1,6-dihydropyridines with application to natural product synthesis; Racemic total synthesis of the fungal metabolite collybolide

Spurlin, Sean (2023-08-09) ETD File Embargoed

Azaheterocycles, a common feature of many bioactive natural products, are still challenging motifs to construct in an asymmetric fashion. Dihydropyridines are advantageous intermediates in the synthesis of such heterocycles, ...

Enantioselective synthesis of 1,6-dihydropyridines with application to natural product synthesis; Racemic total synthesis of the non-nitrogenous opioid collybolide

Spurlin, Sean (2023-08-06) ETD File Embargoed

Purine Carbocyclic Nucleside Analogues as Antiviral Agents

Chen, Qi (2010-12-07)

The carbocyclic nucleosides aristeromycin and neplanocin A are two of the most potent inhibitors of S-adenosylhomocysteine hydrolase, an enzyme that plays a critical role in methyl transfer reactions during a viral replication ...

Regio- and Enantioselective Synthesis of N-alkyl 1,2- and 1,6-dihydropyridines through Rhodium-Catalyzed Nucleophilic Dearomatization

Robinson, Donovan (2022-07-28)

Nonaromatic nitrogen heterocycles, particularly the ones containing one or multiple stereogenic centers, are common structural motifs in bioactive natural products and continue to be challenging synthetic targets. The ...