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Browsing by Author "Schneller, Stewart W."
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Exploring sinefungin analogs as potential antiviral agents
Shulyak, Tetyana (2005-08-15)
Sinefungin bears a strong structural resemblance to S-adenosylmethionine and S-adenosylhomocysteine and, therefore is one of the most potent inhibitors of viral mRNA methyl transferase. Besides antiviral activity, sinefungin ...
Investigations into 5ꞌ-Extended 3-Deazaaristeromycin Derivatives
Lashley, Dana (2014-05-02)
Nucleosides have provided a plentiful source in structural leads in antiviral drug discovery. Included in this class of compounds are the carbocyclic nucleosides, which because of the presence of a cyclopentyl moiety, offer ...
Roles of Two Interhelical Insertions in Catalase-peroxidase Catalysis: Tracing the Impact of Peripheral Protein Structures on Heme Enzyme Function
Li, Yongjiang (2005-08-15)
Monofunctional peroxidases and bifunctional catalase-peroxidases share almost superimposable active sites, yet peroxidases lack appreciable catalase activity. Moreover, catalase-peroxidases catalyze both catalase and ...