Browsing by Author "Shen, Jianzhong"

Now showing items 1-16 of 16

Can nutrition strategies, such as fiber and ketone supplementation, ameliorate the negative effects of high salt consumption on vascular health and immune cell phenotypes?

Linder, Braxton (2024-04-29) ETD File Embargoed

Background: Consuming high dietary salt (HS) is prevalent in the western diet and does not appear to be decreasing. HS consumption is the leading modifiable risk factor for the development of hypertension and subsequent ...

Deep tissue imaging of B16 melanoma in mice by Multispectral Optoacoustic Tomography

Bahauddin, Ammar (2022-06-23) ETD File Embargoed

Melanoma is an aggressive type of skin cancer that can metastasize to draining lymph nodes and distant organs. Early detection of melanoma holds the promise of improved patient outcomes by enabling earlier surgical ...

Development of functional capacity and bactericidal activity in myeloid cells during GM-CSF driven differentiation

Olatunde, Adesola (2018-07-18)

Dendritic cells (DC) form an interface between the innate and adaptive immune systems. DC respond to infection or inflammatory signals by orchestrating other immune cells to perform protective functions. These include ...

Identification and Characterization of Molecular Correlates of Disease in Invasive Streptococcus and Staphylococcus Infection Models

Davis, Richard IV (2015-07-29)

Invasion into the host vasculature marks a dangerous, and often times fatal, complication of bacterial infections. One such severely invasive bacterium, Streptococcus pyogenes, is estimated to affect 18 million people ...

Identification of A New Pharmacological Modulator for P2Y2 Receptor Activity

Alsadah, Eiman (2018-04-23)

P2Y2 is a G-protein-coupled membrane receptor activated by ATP or UTP nucleotides. They play major roles in cellular physiology in different aspects including inflammatory responses and apoptosis. Therefore, P2Y2 receptor ...

Myocardial Ischemia/Reperfusion Injury and Cardioprotection: Novel Roles of Frataxin and Uridine Triphosphate

AlAsmari, Abdullah (2017-04-21)

Ischemia reperfusion (IR) injury in cardiac myocytes is well known to provoke membrane damage that is mediated by oxygen free radicals and that is associated with iron accumulation, energy dysregulation and opening of the ...

Non-platelet Purinergic Signaling and Tissue Factor Expression

Liu, Yiwei (2015-12-14)

Objective—Our group found previously that human coronary artery endothelial P2Y2 receptor mediates tissue factor (TF) up-regulation at mRNA and protein levels. The exact mechanism remains unknown and can involve increased ...

P2Y2 Receptor Biased Signaling in Control of Vascular Inflammation

Lingxin, Zhang (2016-12-09)

Vascular inflammation plays a critical role in the pathogenesis of endotoxic shock and sepsis. Bacterial endotoxins like lipopolysaccharide (LPS) are biologically active substances that initiate the inflammatory response ...

The P2Y2 Receptor Control of Hyperglycemia-induced Insulin Resistance in Human Hepatocytes: A Unified Mechanism for Metformin

SENFELD, JARED (2022-05-01) ETD File Embargoed

According to the International Diabetes Federation, in 2021, 537 million adults were living with diabetes, and another 541 million adults were at increased risk of developing T2D (Facts & Figures, 2021.) Obesity, the most ...

Real-time Monitoring of Staphylococcus Aureus Biofilm Formation Under Flow Conditions in Microfluidic Chambers

Al Mouslem, Abdulaziz Khalid (2020-07-21) ETD File Embargoed

Staphylococcus aureus (S. aureus) causes most of life-threatening infections such as endocarditis, osteomyelitis and sepsis. Since biofilm development is often a key factor in the development of an infection of indwelling ...

Role of Adipocyte P2Y2 Receptor in Adipogenesis and Insulin Resistance

Qian, Shenqi (2022-05-03) ETD File Embargoed

Objective -- It has been known that obesity and type 2 diabetes are associated with inflammation and insulin resistance and that adipose tissue contributes to insulin sensitivity and glucose homeostasis. Also, it was ...

Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease

Shi, Yi (2022-04-14) ETD File Embargoed

Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling ...

Role of P2Y2 Receptor in Metformin-Improved Insulin Resistance in Skeletal Muscle Cells

Nasrullah, Mohammed (2019-07-11) ETD File Embargoed

Abstract Objective—It has been shown that high extracellular glucose promotes ATP release in different cells, but its biological significance is not clear. Also, it has been reported that extracellular ATP either increase ...

Role of the P2Y2 receptor/tissue factor axis in endotoxemia and atherothrombosis

Peng, Qianman (2021-12-06) ETD File Embargoed

Inflammation and coagulation play a critical role in the pathogenesis of thrombosis. Biologically active substances initiate the inflammatory response in vascular endothelial cells (ECs) and immune cells, including ...

Staphylococcal and Streptococcal Biotechnology: Utilization of Bacterial Tools to Advance Preclinical Research and Healthcare

Muse, Charlotte (2023-08-03) ETD File Embargoed

Existing within microcosms of their own making, bacteria sculpt the surrounding environment by responding to the current climate or altering their habitat for protection and survival. The net effect of the bacterium’s ...

Strategies for Monitoring Pathologic Conditions and Treatment Efficacy in Murine Models

Brannen, Andrew (2016-12-09)

On the surface, the pathologies of infectious disease and cancer appear fundamentally different; however, there exist several commonalities including pharmacological targets and resistance mechanisms, immune response, and ...