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Browsing by Author "Smith, Bruce"

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Australian Labradoodle Dystrophinopathy: A Novel Canine Model for the Study of Duchenne Muscular Dystrophy Cardiomyopathy 

Shrader, Stephanie (2020-04-22)
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that results in progressive damage to both skeletal and cardiac myocytes. As a result of improved ventilatory care, mortality in affected patients is ...

In vitro anti-tubulin effects of mebendazole and fenbendazole on J3T canine glioma cells 

Lai, Serene (2016-08-24)
Benzimidazole anthelmintics have reported anti-neoplastic effects both in vitro and in vivo. The purpose of this study was to evaluate the in vitro chemosensitivity of canine glioma J3T cells to mebendazole and ...

Investigating HCAR and FAN1 Variants as Inherited Risk Factors of Breast Cancer 

McGuire Sams, Cierla (2022-04-22)  ETD File Embargoed
Inherited genetic risk factors in known breast cancer (BC) susceptibility genes increase an individual’s overall lifetime risk of developing BC but explain only ~35% of hereditary BC cases. Therefore, additional BC ...

Methods for Isolating Canine Mast Cell Progenitors, Melanocytes, and Keratinocytes 

Flaat, Taylor (2020-04-21)
One of the most difficult aspects of employing precision medicine in the treatment of cancer is determining the best targets to treat within the tumor. A trademark of cancers is that, while two patients may present similar ...

Minimally invasive routes of AAV administration to treat GM1 gangliosidosis 

Gross, Amanda (2020-04-17)
GM1 gangliosidosis is a lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (βgal), which results in the accumulation of GM1 ganglioside and fatal neurodegeneration. In the human type II (late ...

Multilevel Targeting of Canine Adenovirus Type 2 (CAV2) to Expand Oncolytic Virotherapy in Canine Tumors 

Sajib, Abdul Mohin (2020-04-06)
Oncolytic virotherapy is a promising therapeutic approach designed to selectively eradicate cancer cells but to spare normal cells. Oncolytic adenoviruses (Ad) are an outstanding and common vehicle for efficient cancer ...

Nonequilibrium Thermodynamics and Fitness Costs Associated with Information Preservation May Explain Longevity Differences between Species 

Augsburger, Brett (2016-05-05)
The aging process in most organisms is enormously complex, involving a multitude of integrated molecular pathways that define and modulate the gradual cellular, tissue and system-level changes that evoke the aging phenotype. ...

Novel Approaches to the Molecular Characterization of Primary Canine Osteosarcoma 

Nance, Rebecca (2023-07-24)  ETD File Embargoed
Osteosarcoma (OSA) is an aggressive malignant bone tumor that often affects pediatric humans as well as dogs. Canine OSA shares many similarities with the human condition, including clinical presentation and molecular ...

Role of IL-27 in HSV-1-induced Herpetic Stromal Keratitis 

Antony, Ferrin (2024-04-12)  ETD File Embargoed
Herpes Stromal Keratitis (HSK) results from ocular infection with Herpes simplex virus-1 (HSV-1) and is one of the leading causes of infectious blindness. After primary lytic infection in the facial region, the virus ...

Role Of Integrin-Linked Kinase In Synaptic Plasticity And Memory:o Diabetes/Alzheimer’s Link 

Ali, Engy (2012-05-03)
Type 2 diabetes mellitus (T2DM) has recently been proven to be a risk factor for cognitive dysfunction and dementia such as Alzheimer’s disease (AD). However, the exact pathophysiology of cognitive dysfunction in patients ...

Selection of Promiscuous Anti-Cancer Phage Proteins for Tumor Targeted Nanomedicines 

Gross, Amanda (2015-07-28)
Cancer remains one of the leading causes of death and requires novel approaches in both management and treatment. Tumor targeting ligands have been identified to a variety of human cancer cell lines using phage display ...