Browsing by Author "Suh, Sang-Jin"

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Characterization of the global regulatory network of trans-translation in Pseudomonas aeruginosa

Li, Bingyu (2017-07-25)

Recycling stalled ribosomes is a bioenergetically important process for survival and propagation of bacteria. The primary ribosome rescuing mechanism in bacteria is trans-translation which is catalyzed by transfer messenger ...

Characterization of tmRNA function and regulation in Pseudomonas aeruginosa

Wu, Suihan (2013-04-23)

Transfer messenger RNA (tmRNA) encoded by ssrA, is a hybrid RNA with tRNA and mRNA domains that catalyzes recycling of stalled ribosomes. This bioenergetically important process appears to play diverse functions in the ...

Comparative Analyses and Structural Modeling of RNAs Participating in Non-Canonical Initiation of Protein Synthesis

Burks, Jody (2010-12-09)

Transfer-messenger RNA and the Internal Ribosomal Entry Site (IRES) RNAs of Foot and Mouth Disease Virus (FMDV) and Bovine Viral Diarrhea Virus (BVDV) play important roles in trans-translation and cap-independent protein ...

Development of functional capacity and bactericidal activity in myeloid cells during GM-CSF driven differentiation

Olatunde, Adesola (2018-07-18)

Dendritic cells (DC) form an interface between the innate and adaptive immune systems. DC respond to infection or inflammatory signals by orchestrating other immune cells to perform protective functions. These include ...

Development Toward a Bovine Salmonella Model and a Bacteriophage Treatment Cocktail to Reduce Salmonella Peripheral Lymph Node Carriage in Calves

Shirley, James (2016-05-05)

Non-typhoidal salmonellosis is the leading bacterial cause of human foodborne disease in the United States and is responsible for numerous hospitalizations and deaths each year. Although several strategies have been ...

GlpR Regulates the Glyoxylate Pathway and Virulence Factor Production by Pseudomonas aeruginosa

Scoffield, Jessica (2012-05-10)

Pseudomonas aeruginosa infections are the leading cause of morbidity and mortality for cystic fibrosis (CF) patients. P. aeruginosa establishes life-long infection in the CF lung by utilizing various adaptation strategies ...

Identification of genes involved in the production of a novel antifungal agent (7, 10, 12-trihydroxy-8(E)-octadecenoic acid) in Pseudomonas aeruginosa

Cofield, Jessica (2009-08-04)

The gram-negative bacterium Pseudomonas aeruginosa catalyzes the conversion of ricinoleic acid into a novel trihydroxy fatty acid, 7, 10, 12-trihydroxy-8(E)-octadecenoic acid (TOD), that has a potent antifungal activity ...

Improving the phage-displayed peptide probes for pathogen detection

Tong, Zhou (2014-12-10)

In order to minimize the danger to the public from pathogen outbreaks, it is imperative to rapidly identify the infectious agent so appropriate response can be mounted and prevent dissemination of the organism. An ideal ...

Methyl-coenzyme M reductase: Elucidating the process of activation and study of the effect of the methanogenesis inhibitor 3-nitrooxypropanol

Prakash, Divya (2014-12-17)

To use methane as a biocatalyst, it is important to establish a cell free system to convert the inactive form of methane forming enzyme i.e Methyl-coenzyme M reductase (MCR) to the active form. MCR catalyzes the reversible ...

Survival and Transmission of Selected Pathogens on Airplane Cabin Surfaces and Selection of Phages Specific for Campylobacter jejuni

Vaglenov, Kiril (2014-04-28)

We determined the limits of survival and transmission of Escherichia coli O157:H7 and methicillin-resistant Staphylococcus aureus (MRSA) on common surfaces found in the cabin of a civil aircraft. The two pathogens were ...