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Browsing by Author "Suppiramaniam, Vishnu"
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Adiponectin alters hippocampal synaptic function: a mechanism for amelioration of synaptic deficits in a mouse model of Alzheimer’s disease
Bloemer, Jenna (2019-12-06)
The hormone adiponectin, the most abundant adipokine, is an important regulator of metabolic function, and recent evidence suggests that adiponectin plays an essential role in the cross-talk between adipose tissue and brain ...
Differential Modulation of Glutamatergic Synaptic Transmission by Polysialic Acid
Sims, Catrina (2007-12-15)
Controlled modulation and regulation of glutamate receptors are essential for synaptogenesis and synaptic plasticity. The two major types of excitatory glutamate receptors found at the synapse are AMPA and NMDA, which ...
Elucidating the Cognitive Deficits following Doxorubicin treatment
Alhowail, Ahmad (2014-12-11)
Chemotherapeutic drugs are effective in the treatment of various types of tumors;
however, the optimal clinical effectiveness is limited due to secondary effects including
cognitive impairment, also known as “chemobrain”, ...
Elucidation of Cognitive Deficits Associated with Doxorubicin Treatment and Ameliorating Effects of Phenyl-2-Amino-Ethyl Selenide (PAESe)
Alhowail, Ahmad (2017-04-25)
A growing body of evidence suggests that acute and chronic cognitive impairments are a common side-effect of chemotherapy. In fact, chemotherapy induced cognitive deficits or “chemobrain” are known to occur in up to 75% ...
Elucidation of the mechanism of learning and memory deficits in adolescent offspring due to prenatal cannabinoid exposure
Pinky, Priyanka (2020-07-21) ETD File Embargoed
Cannabis is now one of the most commonly used illicit substances among pregnant and lactating women. This is particularly concerning given that developmental exposure to cannabinoids has been demonstrated to induce enduring ...
Essential Role for P62 in AMPA Receptor Trafficking and Synaptic Plasticity
Jiang, Jianxiong (2008-05-15)
AMPA-type glutamate receptors (AMPARs) mediate major fast excitatory synaptic transmission in the mammalian central nerve system (CNS). Trafficking of AMPA receptors to and away from the postsynaptic membrane is fundamental ...
Examining the metabolic, physiologic and chronobiologic effects of Western diet-induced obesity in a mouse model
Woodie, Lauren (2019-12-05)
Obesity is a major public health concern that can result from consuming a Western diet (WD), characterized by a diet high in fat and sugar, including sugar sweetened beverages. A proposed treatment for WD-induced obesity ...
Glutamate receptor mediated bi-directional plasticity is responsible for reconsolidation of fear memories
Bhattacharya, Subhrajit (2015-12-16)
Retrieval of a memory appears to render it unstable until the memory is once again re-stabilized or reconsolidated. Although the occurrence and consequences of reconsolidation have received much attention in recent years, ...
Insulin Signaling and Synaptic Physiology: Insights into the Pathogenesis of Alzheimer's Disease
Shonesy, Brian (2009-07-07)
An emerging hypothesis is that desensitization of the neuronal insulin receptor (central insulin resistance) may contribute to the pathogenesis of Alzheimer’s disease (AD). It is believed that deficits in glutamatergic ...
Investigate the dopaminergic neurotoxicity profile of designer drugs (Piperazine derivatives)
Almaghrabi, Mohammed (2018-05-14)
Different botanical derived, or synthetic addictive substances have been “misused” and/or “abused” for centuries around the world. To overcome the abuse by these substances, strict legal laws were constituted globally. ...
Investigating the Role of Aging and Pathological Tau in Alzheimer's Disease
Setti, Sharay (2021-12-06) ETD File Embargoed
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by
accumulation of plaques made of insoluble beta-amyloid protein, neurofibrillary tangles
containing hyperphosphorylated tau protein, ...
Mechanisms Underlying Myeloperoxidase Inhibition: Evaluating the Efficacy and Safety of Anti-inflammatory MPO Inhibitors Designed to Limit the Generation of Reactive Oxygen and Nitrogen Species
Huang, Jiansheng (2015-07-24)
Myeloperoxidase (MPO), a heme-containing peroxidase, plays a critical role in the innate immune response by producing hypochlorous acid. MPO-mediated oxidation is also associated with chronic obstructive pulmonary disease ...
Molecular mechanisms underlying synaptic dysfunction in Aging Alzheimer's disease and Diabetes
Kariharan, Thiruchelvam (2012-01-19)
Alzheimer’s disease (AD) and diabetes (DB) contribute to the development of early brain aging and cognitive dysfunction. Mechanistic basis of cognitive dysfunction in AD and DB is not well elucidated. Resistance to age ...
Neuroprotection against Methamphetamine Induced Neurotoxicity: Applications for Parkinson’s Disease
Thrash, Bessy (2009-05-04)
Parkinson’s disease is a progressive neurodegenerative disorder associated with selective degeneration of nigrostriatal dopaminergic neurons. It is the most common of the neurodegenerative movement disorders, affecting ...
Nicotine and Integrin Linked Kinase Interplay Modulates Synaptic Plasticity Mechanisms Required for Memory
Aljadani, Fatimah (2015-09-23)
Integrin Linked Kinase (ILK) has been associated with forms of synaptic plasticity required for memory. Nicotine, at low-concentration improves memory but higher concentrations impart learning and memory deficits. The ...
Pharmacokinetics of Voriconazole in Horses and Alpacas
Chan, Hui (2008-05-15)
Voriconazole is a new antifungal drug that has shown effectiveness in treating serious fungal infections and has the potential for being used in large animal veterinary medicine. The objectives of this study were to ...
Phosphodiesterase 5 Inhibition on Dopaminergic and Glutamatergic Neurotransmission: Implications for Memory Enhancement
Uthayathas , Subramaniam (2009-02-06)
Phosphodiesterases belongs to a family of proteins that metabolize cyclic nucleotides. There are at present eleven types of Phosphodiesterases been isolated and shown to be expressed in various tissues. Phosphodiesterase ...
Prenatal Nicotine Exposure and Glutamatergic-Cholinergic Interplay
Buabeid, Manal (2013-12-02)
Smoking in pregnant women is reported as a risk factor in neurobehavioral alterations such as learning and memory deficits. Prenatal exposure of nicotine (6mg/kg /day) in animal models induces memory impairment associated ...
Prenatal Nicotine Exposure and Molecular Mechanisms of Memory Impairment
Parameshwaran, Kodeeswaran (2008-08-15)
Prenatal nicotine exposure in the form of active maternal smoking is a major risk factor for several harmful effects in the children. These effects include reduced motor skills, poor IQ scores and most importantly learning ...
Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease
Shi, Yi (2022-04-14) ETD File Embargoed
Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling ...