Browsing by Author "Tao, Ya-Xiong"

Now showing items 1-16 of 16

Allosteric modulation of human melanocortin-4 receptor (MC4R) by zinc and copper ions and characterization of spotted sea bass MC4R

Hou, Zhi-Shuai (2020-07-20)

Since the metal ions have been shown to play an important role in regulating signal transduction of G protein-coupled receptors (GPCRs), we investigated whether the Zn2+ and Cu2+ regulate the pharmacology of human ...

Determination of Safe and Effective Dosing Regimens for Nonsteroidal Anti-inflammatory Drugs in African and Asian Elephants.

Kottwitz, John-Ryan (2019-07-29) ETD File Embargoed

Arthritis and foot disease are well documented conditions affecting captive elephants that are frequently treated with nonsteroidal anti-inflammatory drugs (NSAIDs). An important consideration regarding efficacy and safety ...

Effect of Increasing Intra-Abdominal Pressures on Hemodynamic Variables and Biomarkers of Ischemia and Acute Inflammation in the Horse

Munsterman, Amelia Suzanne (2017-04-20)

Intra-abdominal hypertension (IAH) is defined as increased pressure within the confines of the abdominal cavity. As pressure rises, ischemia of the splanchnic organs will result from direct compression of the organs and ...

The Effects of Lactational Exposure to Soy Isoflavones on Testicular Function in the Rat

Napier, India (2011-08-09)

Testosterone, the male androgen responsible for maintaining the male phenotype, is produced by testicular Leydig cells. Leydig cells express estrogen receptors and are therefore regulated by estrogen. Soybeans predominantly ...

Examining the metabolic, physiologic and chronobiologic effects of Western diet-induced obesity in a mouse model

Woodie, Lauren (2019-12-05)

Obesity is a major public health concern that can result from consuming a Western diet (WD), characterized by a diet high in fat and sugar, including sugar sweetened beverages. A proposed treatment for WD-induced obesity ...

Functional characterization and pharmacological rescue of the human and porcine neural melanocortin receptors

Fan, Zhenchuan (2008-08-15)

During the past decade, numerous studies showed that both melanocortin-3 and -4 receptors (MC3R and MC4R) are critically involved in regulation of mammalian energy balance. The MC4R plays a vital role in regulation of food ...

Functional characterization of novel naturally occurring mutations in human melanocortin-3 receptor gene

Yang, Fan (2012-12-03)

The prevalence of obesity is increasing in both developed and developing countries. Obesity is a disorder of energy homeostasis, associated with increased risk of diabetes mellitus, cardiovascular diseases and certain types ...

Human melanocortin-3 receptor: structure-function relationship of DPLIY motif and helix 8 and biased signaling

Yang, Zhao (2016-05-05)

The melanocortin-3 receptor (MC3R) is a member of family A G protein-coupled receptors (GPCRs). The MC3R remains the most enigmatic of the melanocortin receptors with regard to its physiological functions, especially the ...

Human melanocortin-4 receptor: structure-function relationship of transmembrane domain 3 and biased signaling

Mo, Xiu-Lei (2013-07-15)

The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor critical for maintaining energy homeostasis. Transmembrane domain 3 (TM3) of MC4R contains residues that are suggested to be essential in ligand binding ...

Pharmacological characterization and functional rescue of human melanocortin-4 receptor mutants

Huang, Hui (2014-07-11)

The melanocortin-4 receptor (MC4R) plays an important role in regulating food intake and energy expenditure. Previous studies reported that the transmembrane domain 6 was important in activating several G protein-coupled ...

Pharmacological characterization and functional rescue of the giant panda and human melanocortin-4 receptors

Wang, Wei (2017-07-25)

The melanocortin-4 receptor (MC4R) is a member of family A rhodopsin-like G protein-coupled receptors. It is well established that MC4R is critically involved in regulating food intake and energy expenditure in mammals. ...

Pharmacological Characterization of Canine Melanocortin-4 Receptor and Its Natural Variant V213F

Yan, Jin (2009-08-03)

Obesity is becoming one of the most significant public health problems all over the world, especially in some developed countries. During the past decade, genetic factors associated with obesity have gained more attention. ...

Pharmacological characterization of fish melanocortin-4 and melanocortin-5 receptors

Liu, Ting (2021-07-12)

The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. The melanocortin-5 receptor (MC5R) has been implicated in the regulation of exocrine gland secretion, ...

Protective role of adiponectin in volume overload-induced heart failure

Wang, Lili (2014-12-09)

Heart failure (HF) is approaching epidemic proportions in United States. Adiponectin is a protein hormone that plays an important role in modulating glucose uptake and fatty acid β-oxidation in the heart. It has been well ...

Role Of Integrin-Linked Kinase In Synaptic Plasticity And Memory:o Diabetes/Alzheimer’s Link

Ali, Engy (2012-05-03)

Type 2 diabetes mellitus (T2DM) has recently been proven to be a risk factor for cognitive dysfunction and dementia such as Alzheimer’s disease (AD). However, the exact pathophysiology of cognitive dysfunction in patients ...

Structure-function relationship of human melanocortin-4 receptor and characterization of fish neural melanocortin receptors

Yang, Likun (2019-07-19)

The neural melanocortin receptors, including melanocortin-3 and -4 receptors (MC3R and MC4R), are two important factors in regulation of energy homeostasis. MC3R primarily regulates feed efficiency and nutrient partitioning, ...