Browsing by Department "Veterinary Anatomy, Physiology, and Pharmacology"
Now showing items 1-18 of 18
Adiponectin Expression and Oxidative Stress in Hearts of Mice Fed a High-fat Diet
(2013-07-09)
Evidence suggests that excess superoxide generation leading to oxidative stress and/or the reduced capacity of organisms to regulate oxidative/redox environments play a major role in the initiation and progression of obesity ...
Bony Abnormalities in Feline Models of GM2 Gangliosidosis
(2014-07-09)
This study seeks to explore and quantify bony deformities in feline models affected with GM2 gangliosidosis with emphasis on long bones and cervical vertebrae, based on previous diagnostics exhibiting cervical spinal cord ...
Characterization of the HCA2 Receptor in a Murine and a Feline Model of Human Obesity
(2015-12-10)
Background. There is mounting evidence that the hydroxycarboxyilic acid 2 (HCA2) receptor, which is present on both adipocytes and immune cells, plays an important role in modulating cross-talk between metabolic and immune ...
The Effect of Mutations in Type II Topoisomerases on Fluoroquinolone Resistance in Clinical Canine Urine Escherichia coli Isolates
(2011-04-12)
A series of experiments were preformed in order to validate a rapid FRET-PCR based assay for the detection of fluoroquinolone resistance in small animal Escherichia coli urinary tract infection (UTI) isolates. Three hundred ...
The Effects of Lactational Exposure to Soy Isoflavones on Testicular Function in the Rat
(2011-08-09)
Testosterone, the male androgen responsible for maintaining the male phenotype, is produced by testicular Leydig cells. Leydig cells express estrogen receptors and are therefore regulated by estrogen. Soybeans predominantly ...
Epidemiology of the virulence and antimicrobial resistance of Escherichia coli from canine and feline clinical isolates.
(2014-12-17)
Escherichia coli resistance impacts the veterinary professional because of therapeutic failure and the public health significance. The lack of national monitoring programs in small animal practices limits evidence-based ...
Heat stress and ischemia/reperfusion cause oxidative stress via NADPH oxidase in hypothalamic neurons
(2009-04-29)
Ischemia/reperfusion-related injuries are associated with a wide range of diverse disorders including but not limited to aging, heat stroke, diabetes and Alzheimer’s disease. Ischemia/reperfusion is known to cause oxidative ...
Human melanocortin-3 receptor: structure-function relationship of DPLIY motif and helix 8 and biased signaling
(2016-05-05)
The melanocortin-3 receptor (MC3R) is a member of family A G protein-coupled receptors (GPCRs). The MC3R remains the most enigmatic of the melanocortin receptors with regard to its physiological functions, especially the ...
Human melanocortin-4 receptor: structure-function relationship of transmembrane domain 3 and biased signaling
(2013-07-15)
The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor critical for maintaining energy homeostasis. Transmembrane domain 3 (TM3) of MC4R contains residues that are suggested to be essential in ligand binding ...
Molecular Mechanisms of Neuroprotection by an Alternative Drug Scutellaria lateriflora
(2014-07-21)
Anxiety is one of the most prevalent neuropsychological disorders around the world. In the United States of America (USA), it is a serious health problem affecting a large number of people and is considered as one of the ...
Novel Pleiotropic Effects of Niacin
(2012-07-10)
Introduction. Obesity is associated with a chronic low-grade inflammation of the adipose tissue that has been linked to obesity-related comorbidities, such as insulin resistance and cardiovascular disease. Niacin exerts ...
Pharmacological characterization and functional rescue of human melanocortin-4 receptor mutants
(2014-07-11)
The melanocortin-4 receptor (MC4R) plays an important role in regulating food intake
and energy expenditure. Previous studies reported that the transmembrane domain 6 was
important in activating several G protein-coupled ...
Pharmacological Characterization of Canine Melanocortin-4 Receptor and Its Natural Variant V213F
(2009-08-03)
Obesity is becoming one of the most significant public health problems all over the world, especially in some developed countries. During the past decade, genetic factors associated with obesity have gained more attention. ...
Protective role of adiponectin in volume overload-induced heart failure
(2014-12-09)
Heart failure (HF) is approaching epidemic proportions in United States. Adiponectin is a protein hormone that plays an important role in modulating glucose uptake and fatty acid β-oxidation in the heart. It has been well ...
Regulation of Leydig Cell Differentiated Function by the Industrial Chemical Bisphenol A (BPA)
(2012-08-02)
Exposure of the population to bisphenol A (BPA) is significant due to its extensive use in the manufacture of a wide variety of consumer products, including polycarbonate plastics and epoxy resins. However, there is concern ...
Regulation of Potassium Channel in Ventricular Myocytes of Rat Following Volume Overload
(2009-04-13)
Heart failure (HF) is a leading cause of death in the US. Among the deaths of
patients with HF, up to 50% are sudden and unexpected. The sudden deaths have been
related to the lethal ventricular arrhythmias such as ...
The Role of gyrA, Efflux Pump and Integrons in Mediating the Emergence of Multi-Drug Resistance among Canine and Feline Pathogenic Clinical Escherichia coli
(2009-05-01)
A series of experiments was performed to elucidate the emergence of fluoroquinolone (FQ)/multi-drug resistance (MDR) and the contribution of selected mechanisms of resistance to MDR (i.e. mutations in gyrA, efflux pump, ...
Therapeutic Drug Monitoring and Population Analysis as Applied to Leflunomide and Cyclosporine Therapy in Dogs with Immune-mediated Diseases
(2014-09-10)
Two immunomodulator drugs, leflunomide (teriflunomide is its active metabolite) and cyclosporine, are often monitored in veterinary patients in order to support the design of dosing regimens when used to treat immune-mediated ...