Browsing Auburn Theses and Dissertations by Author "Judd, Robert"

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Adiponectin alters hippocampal synaptic function: a mechanism for amelioration of synaptic deficits in a mouse model of Alzheimer’s disease

Bloemer, Jenna (2019-12-06)

The hormone adiponectin, the most abundant adipokine, is an important regulator of metabolic function, and recent evidence suggests that adiponectin plays an essential role in the cross-talk between adipose tissue and brain ...

Adiponectin Expression and Oxidative Stress in Hearts of Mice Fed a High-fat Diet

Gorman, Teresa (2013-07-09)

Evidence suggests that excess superoxide generation leading to oxidative stress and/or the reduced capacity of organisms to regulate oxidative/redox environments play a major role in the initiation and progression of obesity ...

Altered temporal changes in Ser312-phosphofetuin-A concentrations in response to a glucose challenge in a mouse model of diet-induced obesity and insulin resistance

Okerberg, Carl (2012-07-25)

Recent studies have implicated a role for the liver-secreted glycoprotein fetuin-A in insulin resistance. Fetuin-A negatively regulates insulin action by interacting with the activated insulin receptor and inhibiting ...

Central Leptin, But Not Central Insulin, Attenuates the Decrease of Adiponectin Concentrations and Increases Insulin Sensitivity in Streptozotocin (STZ)-Induced Diabetic Rats

Wang, Jinpin (2005-08-15)

Central leptin increases peripheral insulin sensitivity through unknown mechanisms. Central insulin signaling may also contribute to peripheral insulin sensitivity. To clarify the relationships among central leptin, central ...

Characterization and differentiation of bacteria by hyperspectral analysis

Riggs, Rebecca (2019-07-19) ETD File Embargoed

Characterization and differentiation of microorganisms by hyperspectral analysis is a promising alternative to conventional techniques in clinical, food, and environmental microbiology to be used as a rapid, non-destructive ...

Characterization of Adiponectin in the Canine

Brunson, Brandon (2007-08-15)

Obesity is the most common nutritional disorder observed in small animal medicine. Obesity in dogs can result in numerous complications, including traumatic and degenerative orthopedic diseases, cardiopulmonary compromise, ...

Characterization of the HCA2 Receptor in a Murine and a Feline Model of Human Obesity

Graff, Emily (2015-12-10)

Background. There is mounting evidence that the hydroxycarboxyilic acid 2 (HCA2) receptor, which is present on both adipocytes and immune cells, plays an important role in modulating cross-talk between metabolic and immune ...

Development of thermally regulated homogeneous assays and droplet-based microfluidic tools for probing secretion dynamics from pancreatic and adipose tissues

Hu, Juan (2018-07-24)

Cells can transmit signals and adapt to microenvironment variations rapidly with dynamic processes, such as biomolecule secretion for signal delivery. Dynamic, oscillatory secretion is expected to exist in many cell ...

Diet-induced Gut Microbiome and Colon Transcriptome Changes in C57BL/6J, C57BL/6N and HCA2-/- Mice

Li, Zhuoyue (2020-11-24) ETD File Embargoed

Genetic variation drives phenotypic and gut microbiome diversity, while also regulating metabolism and immune responses. C57BL/6J and C57BL/6NCrl inbred mice strains have different metabolic phenotypes in response to ...

Differential Effects of Niacin on Adipose Tissue Inflammation, Hepatic Function, and Gut Microbiota Composition in C57BL/6J and B6129SF2/J Mice

Fang, Han (2019-07-18) ETD File Embargoed

Background. Obesity is associated with adipose tissue inflammation, development of nonalcoholic fatty liver disease (NAFLD) and altered gut microbiota composition. Niacin is beneficial in inhibiting obesity-associated ...

The Effects of St. John's Wort on the Pharmacokinetics of Corticosteroid and Non-Steroidal Drug Preparations

Bell, Edward (2005-08-15)

St. John’s Wort is a flowering plant whose extracts have gained increasing popularity in the treatment of mild to moderate depression. This investigation examined the impact of long-term St. John’s Wort administration upon ...

Fibroblast Growth Factor-21 (FGF21) in Domestic Cats

Brinker, Emily (2023-04-26) ETD File Embargoed

Fibroblast growth factors (FGFs) are a group of structurally homologous yet functionally pleiotropic proteins. Unlike canonical and intracellular FGFs, the FGF19 subfamily, which includes FGF15/19, FGF21, and FGF23, act ...

Heat Stress Induces Downregulation of Hippocampal Superoxide Dismutase-1; a Possible Mechanism for Heat-Related Neuronal Cell Death

El-Orabi, Naglaa (2006-12-15)

Exertional heat injury represents a major risk for people working or exercising in hot environments. Currently, no pharmacological therapies are available and little is known about the molecular response to heat stress in ...

Molecular Mechanisms Associated with Canine Cyclic Hematopoiesis

Meng, Ronghua (2008-05-15)

Canine cyclic hematopoiesis (CH) is an autosomal recessive disorder characterized by 12-14 day neutrophil cycles, a diluted coat color, and platelet storage pool disease. Canine CH is caused by a mutation in AP3B1, encoding ...

Myelin Deficits and Intravenous Gene Therapy in Feline Sandhoff Disease

Maguire, Anne (2021-07-27)

Sandhoff Disease (SD) is a neurodegenerative lysosomal storage disease (LSD) that results in the death of children before 4 years of age. Because there are no FDA-approved therapies available, current treatment strategies ...

Novel Analgesics and the Impact of Route of Administration in the Horse

Davis, Heather (2019-12-05)

primary goal of this dissertation was to describe the disposition of novel analgesics and the impact of their administration on the equine patient. In order to support this aim, a novel, non-septic, transient model of ...

Pharmacodynamic Effects of Pioglitazone on High Molecular Weight Adiponectin Concentrations and Insulin Response after Oral Sugar in Equids

Legere, Rebecca (2019-07-10)

Chronic insulin dysregulation is challenging to manage with pharmaceuticals in horses. Pioglitazone improves insulin sensitivity in humans, and the pharmacokinetics of pioglitazone have been evaluated in horses. The ...