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Browsing Auburn Theses and Dissertations by Author "Abbott, Kodye"

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Repurposing FDA Approved Drugs to Antagonize Pregnane X Receptor Mediated Chemoresistance 

Abbott, Kodye (2019-12-05)  ETD File Embargoed
Human pregnane X receptor (hPXR) is an orphan nuclear receptor that regulates key drug metabolism enzymes (DMEs) and drug-transport proteins (DTPs), including Cytochrome p450 3A4 (CYP3A4) and multidrug resistance protein ...