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Browsing Auburn Theses and Dissertations by Author "Graff, Emily"

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Characterization of the HCA2 Receptor in a Murine and a Feline Model of Human Obesity 

Graff, Emily (2015-12-10)
Background. There is mounting evidence that the hydroxycarboxyilic acid 2 (HCA2) receptor, which is present on both adipocytes and immune cells, plays an important role in modulating cross-talk between metabolic and immune ...

Effects of hyperbaric oxygen therapy on inflammatory factors and antioxidant status in dogs after ovariohysterectomy – a pilot study 

Gautier, Anais (2019-07-02)
Hyperbaric oxygen therapy (HBO) is proven to have anti-inflammatory, antioxidant and healing properties in humans and laboratory animals. However, there are relatively few studies about the effects of HBO in companion ...

Fibroblast Growth Factor-21 (FGF21) in Domestic Cats 

Brinker, Emily (2023-04-26)  ETD File Embargoed
Fibroblast growth factors (FGFs) are a group of structurally homologous yet functionally pleiotropic proteins. Unlike canonical and intracellular FGFs, the FGF19 subfamily, which includes FGF15/19, FGF21, and FGF23, act ...

Minimally invasive routes of AAV administration to treat GM1 gangliosidosis 

Gross, Amanda (2020-04-17)
GM1 gangliosidosis is a lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (βgal), which results in the accumulation of GM1 ganglioside and fatal neurodegeneration. In the human type II (late ...

Myelin Deficits and Intravenous Gene Therapy in Feline Sandhoff Disease 

Maguire, Anne (2021-07-27)
Sandhoff Disease (SD) is a neurodegenerative lysosomal storage disease (LSD) that results in the death of children before 4 years of age. Because there are no FDA-approved therapies available, current treatment strategies ...