Browsing Auburn Theses and Dissertations by Author "Judd, Robert L."

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The Apparent Increase in Insulin Sensitivity of Leptin-Treated Rats Appears to be Due to a Decrease in Blood Glucose Concentrations in Response to Fasting

Gragg, Maryanne (2007-12-15)

To distinguish between the effects of insulin stimulation and fasting on blood glucose homeostasis in leptin-treated animals, streptozotocin(STZ)-induced diabetic (STZ-D) and non-diabetic rats given chronic intracerebroventricular ...

Fasting length and hay type effects on metabolic parameters in the horse

Bruce, Ashley (2014-12-10)

Several metabolic disorders in the horse have been associated with post-prandial fluctuations of blood insulin and glucose concentrations in response to the ingredient and/or chemical composition of feedstuffs consumed. ...

Fluoroquinolone-associated mutations in soxS, a transcriptional regulator of AcrAB efflux pump

Lazzaroni, Caterina (2013-11-08)

Escherichia coli is a major cause of urinary tract infections in companion animals and efflux pump over expression has been associated with high-level fluoroquinolone (FQ) resistance. The purpose of this study was to ...

Novel Pleiotropic Effects of Niacin

Wanders, Desiree (2012-07-10)

Introduction. Obesity is associated with a chronic low-grade inflammation of the adipose tissue that has been linked to obesity-related comorbidities, such as insulin resistance and cardiovascular disease. Niacin exerts ...

A Novel Role for Fetuin-A in the Pathophysiology of Glucocorticoid-Mediated Insulin Resistance

Huang, Edmond (2008-05-15)

Fetuin-A (also called alpha2-HS glycoprotein), a phosphorylated protein secreted by the liver, is a physiological inhibitor of the insulin receptor tyrosine kinase (IR-TK). Elevated plasma levels of fetuin-A have been ...

PPM1A Phosphatase is Involved in Regulating Pregnane Xenobiotic Receptor Mediated Cytochrome P450 3A4 Gene Expression

Flannery, Patrick (2014-12-10)

The liver is the most important organ of drug metabolism and plays a major role in the detoxification of both endobiotics and xenobiotics. The process of drug metabolism is undertaken in three distinct phases. Cytochromes ...

Protective role of adiponectin in volume overload-induced heart failure

Wang, Lili (2014-12-09)

Heart failure (HF) is approaching epidemic proportions in United States. Adiponectin is a protein hormone that plays an important role in modulating glucose uptake and fatty acid β-oxidation in the heart. It has been well ...

Sequestosome 1/p62 and TRAF6 are necessary for Akt ubiquitination, translocation and activation

Carter, Andrea (2014-11-24)

Defects in protein-protein interactions of the insulin signaling pathway result in insulin resistance that precedes type 2 diabetes. The protein Akt is the primary modulator of cellular glucose uptake through the GLUT4 ...

Therapeutic Drug Monitoring and Population Analysis as Applied to Leflunomide and Cyclosporine Therapy in Dogs with Immune-mediated Diseases

Sofge, Jameson (2014-09-10)

Two immunomodulator drugs, leflunomide (teriflunomide is its active metabolite) and cyclosporine, are often monitored in veterinary patients in order to support the design of dosing regimens when used to treat immune-mediated ...