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Browsing Auburn Theses and Dissertations by Author "Kaddoumi, Amal"
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Amylin and pramlintide modulate γ-secretase activity and APP processing in lipid rafts
Mousa, Youssef (2019-06-24)
The misfolded amyloid-β (Aβ) peptide is generated in higher amounts in Alzheimer’s disease (AD), making this peptide a clinical hallmark for AD. A major site to produce Aβ is the lipid rafts, which are integral part of the ...
The Blood-Brain Barrier as a Therapeutic Target for Alzheimer’s Disease and Related Disorders
Al Rihani, Sweilem (2019-06-10)
The blood-brain barrier (BBB) is a highly selective and protective membrane that preserves brain homeostasis and prevents the free entry of chemicals, toxins and drugs to the brain. The BBB barrier function is primarily ...
The Evaluation of a Pilot Theory-Based Nutrition Intervention Promoting a Mediterranean diet for the Reduction of Cardiovascular Disease Risk Factors in a High-Risk Population of the Southeastern United States: The Healthy Hearts Program
Willis, Amy (2018-11-30)
In the United States, Cardiovascular disease (CVD) is responsible for 25% of deaths among adults with morbidity rates highest in the southeastern region of the country. Despite studies showing adherence to a Mediterranean-style ...
Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling
Darakjian, Lucy (2020-05-14)
In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...
Targeting Neuroinflammation as a Therapeutic Approach in Alzheimer’s Disease Mouse Model
Abdallah, Ihab (2020-08-24)
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common form of dementia that affects people in their middle age, in the case of familial cases, and the elderly causing significant losses to ...