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dc.contributor.advisorDhanasekaran, Muralikrishnan
dc.contributor.authorAlmaghrabi, Mohammed
dc.date.accessioned2018-05-14T14:40:01Z
dc.date.available2018-05-14T14:40:01Z
dc.date.issued2018-05-14
dc.identifier.urihttp://hdl.handle.net/10415/6226
dc.description.abstractDifferent botanical derived, or synthetic addictive substances have been “misused” and/or “abused” for centuries around the world. To overcome the abuse by these substances, strict legal laws were constituted globally. However, novel and drugs with chemical structures similar to illegal psychoactive drugs substances (with a slight structural change) were manufactured in undercover laboratories to have the same or augmented psychostimulatory effects. Currently, the major classes of designer drugs are piperazines, cathinones, synthetic cannabinoids, synthetic opioids, tryptamines, and phenethylamines. These classes of designer drugs have shown to elicit significant psychostimulatory effect by a different mechanism of action. There are very few reports on the dopaminergic neurotoxicity of piperazine derivatives. However, they have shown to affect various monoaminergic neurotransmission. In the current study, we have synthesized and elucidated the neurotoxic mechanisms of new piperazines.en_US
dc.subjectInterdepartmental Pharmacyen_US
dc.titleInvestigate the dopaminergic neurotoxicity profile of designer drugs (Piperazine derivatives)en_US
dc.typeMaster's Thesisen_US
dc.embargo.lengthen_US
dc.embargo.statusNOT_EMBARGOEDen_US
dc.contributor.committeeClark, Randall
dc.contributor.committeeDeruiter, Jack
dc.contributor.committeeSuppiramaniam, Vishnu


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