Browsing by Department "Pharmacal Sciences"
Now showing items 1-20 of 44
Applications of Mass spectrometry in natural product drug discovery for malaria: Targeting Plasmodium falciparum thioredoxin reductase
(2013-04-23)
Malaria is considered to be the dominant cause of death in low income countries especially in Africa. Malaria caused by Plasmodium falciparum is a most lethal form of the disease because of its rapid spread and the development ...
Carbohydrate Nanoparticles: A Novel Drug Delivery Platform for the Systemic Route
(2006-12-15)
With the phenomenal developments in the fields of biotechnology and molecular biology, the focus in the medical fraternity is shifting towards cellular level intervention. The use of polypeptides, proteins and possibly ...
Cardioprotective mechanisms of PPAR gamma in diabetic heart
(2014-04-23)
Patients with diabetes exhibit significantly altered renin-angiotensin system (RAS). Recently it has been determined that hyperglycemic conditions induce an increase in angiotensin II (AT II) expression; specifically in ...
Chromatographic and Mass Spectral Studies on Mass Equivalent Substituted Phenethlamines Related to MDEA, MDMMA and MBDB
(2006-12-15)
The goal of this project is to evaluate the GC-MS properties of a series of twelve regioisomeric and isobaric ring substituted phenethylamines with identical molecular weight and major fragmentation ions. Three regioisomeric ...
Comparative Stability of Aspirin in CSP Technologies Active-VialTM and Owens- Illinois L-8 Prescription Vials
(2007-05-15)
The traditional way of drug packaging includes a desiccant pouch along with the drug. The desiccant in the vial helps in preventing the drug degradation due to moisture in surrounding environment. This traditional packaging ...
Design, Synthesis and Activity of DNA Minor Groove Alkylators and 2-Methylaristeromycins
(2012-03-15)
Abstract of part I
The DNA structural differences between normal and tumor cells are almost negligible and accordingly, DNA targeting drugs are reserved for serious and life threatening diseases such as cancer. ...
Development of lipid based nanoparticles for melanoma treatment
(2015-02-12)
Melanoma is the most malignant skin cancer with high mortality. Currently, it can be treated multiple ways, such as chemotherapy, immunotherapy and targeted therapy. However, patients under these therapies usually have low ...
Differential Modulation of Glutamatergic Synaptic Transmission by Polysialic Acid
(2007-12-15)
Controlled modulation and regulation of glutamate receptors are essential for synaptogenesis and synaptic plasticity. The two major types of excitatory glutamate receptors found at the synapse are AMPA and NMDA, which ...
Discovery and characterization of synthetic and natural compounds as inhibitors of shikimate kinase from Mycobacterium tuberculosis by LC-MS
(2014-12-10)
With the increasing emergence of drug-resistant tuberculosis (TB) and the complication by HIV co-infection, Mycobacterium tuberculosis (Mtb) remains a challenging target for drug discovery. The shikimate pathway, responsible ...
Dissolution Enhancement of Poorly Water Soluble Drugs
(2011-03-11)
Aqueous solubility is a limiting factor in the oral bioavailability of a certain class of poorly water soluble drugs. A consequence of low aqueous solubility is a slow dissolution rate. For the drugs with low aqueous ...
The Effects of St. John's Wort on the Pharmacokinetics of Corticosteroid and Non-Steroidal Drug Preparations
(2005-08-15)
St. John’s Wort is a flowering plant whose extracts have gained increasing popularity in the treatment of mild to moderate depression. This investigation examined the impact of long-term St. John’s Wort administration upon ...
Elucidating the Cognitive Deficits following Doxorubicin treatment
(2014-12-11)
Chemotherapeutic drugs are effective in the treatment of various types of tumors;
however, the optimal clinical effectiveness is limited due to secondary effects including
cognitive impairment, also known as “chemobrain”, ...
Elucidating the Neurotoxic Effects of Piperazine Derivatives in Human Neuroblastoma Cells through Oxidative Stress, Mitochondrial Dysfunction and Apoptosis
(2015-07-24)
Designer drugs are synthetic structural analogues/congeners of controlled substances with slightly modified chemical structures intended to mimic the pharmacological effects of known drugs of abuse so as to evade drug ...
Elucidating the Role of Integrin Linked Kinase Pathway in Moderate Drinking Prenatal Alcohol Exposed Rat Model
(2015-11-18)
Alcohol and nicotine are well known teratogen which has been reported to have large scale effect on developing fetus. Prenatal alcohol cause many deleterious effect during fetal development which either persist throughout ...
Environmental Toxins and Dopaminergic Neurotoxicity: Novel Neuroprotective Strategies
(2009-08-07)
Parkinson's disease (PD) is a progressive degeneration of dopaminergic neurons in the substantia nigra, leading to massive loss of dopamine in the striatum. Environmental and endogenous neurotoxins are implicated the ...
GC-MS and GC-IRD Studies on Ethoxyphenethylamines Related to MDEA, MDMMA and MDBD
(2009-12-17)
Three regioisomeric 3,4-methylenedioxyphenethylamines having the same molecular weight and major mass spectral fragments of equal mass have been reported as drugs of abuse in recent years. These compounds are 3,4-methyle ...
GC-MS Studies on Methoxymethylene- Substituted Phenethylamines Related to MDA, MDMA, MDEA and MDMMA
(2012-07-25)
This thesis mainly focused on synthesis and analysis approaches of eight methoxymethylene phenethylamine compounds associated with MDMA and MBDB series structures. Gas chromatography- mass spectrometry (GC-MS) methods were ...
Glutamate receptor mediated bi-directional plasticity is responsible for reconsolidation of fear memories
(2015-12-16)
Retrieval of a memory appears to render it unstable until the memory is once again re-stabilized or reconsolidated. Although the occurrence and consequences of reconsolidation have received much attention in recent years, ...
Identification and Characterization of Molecular Correlates of Disease in Invasive Streptococcus and Staphylococcus Infection Models
(2015-07-29)
Invasion into the host vasculature marks a dangerous, and often times fatal, complication of bacterial infections. One such severely invasive bacterium, Streptococcus pyogenes, is estimated to affect 18 million people ...
Inclusion Complexation of Gefitinib with Cyclodextrins
(2008-08-15)
Gefitinib, a very slightly soluble new drug, is used in the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in patients who have previously received chemotherapy. This study examined the ...