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Browsing Auburn Theses and Dissertations by Author "Jeganathan, Ramesh"

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Altered temporal changes in Ser312-phosphofetuin-A concentrations in response to a glucose challenge in a mouse model of diet-induced obesity and insulin resistance 

Okerberg, Carl (2012-07-25)
Recent studies have implicated a role for the liver-secreted glycoprotein fetuin-A in insulin resistance. Fetuin-A negatively regulates insulin action by interacting with the activated insulin receptor and inhibiting ...

Association of DNA Copy Number and Structural Variation with Racial Disparities in Childhood Obesity 

Phillips, Megan (2021-04-21)  ETD File Embargoed
Obesity has become a major public health concern throughout the world. Alabama is 6th highest ranked with obesity in the United States. The development of obesity can be influenced by several factors, such as diet, ...

Diabetes Self-Management Education (DSME) and Medical Nutrition Therapy (MNT) for Type 2 Diabetes Improves Patient Outcomes: A Retrospective Chart Review 

Hardin, Amie (2017-04-21)
Background Diabetes self-management education (DSME) and Medical Nutrition Therapy (MNT) improve patient outcomes; poor reimbursement limits access to care. Objectives The aim was to develop methodology for tracking ...

Effectiveness of Home Gardening in Reducing Food Insecurity and Improving Health in Chacraseca, Nicaragua: A Pilot Study 

Tumwebaze, Joel (2018-12-06)
Nicaragua has a high rate of food insecurity determined by factors such as, poverty, employment, education, social capital and climate change. Home gardening and nutrition education can decrease food insecurity and improve ...

The Efficacy of a Diabetes Self-Management Education and Support Coaching Program for the Ongoing Management of Type 2 Diabetes in North Alabama 

Stanley Chester, Brittannie (2022-05-02)
According to the latest 2020 National Diabetes Statistics Report from the Centers for Disease Control and Prevention, 34.2 million people have diabetes in the United States (10.5% of the population).1 This number has ...

Eight weeks of supplementation with Vitamin D3 improves serum concentrations but does not affect strength or body composition in young-adult resistance training females 

Zandieh, Nilophar (2023-12-11)  ETD File Embargoed
Various lines of evidence suggest vitamin D exerts a range of beneficial effects in skeletal muscle. Nonetheless, there are limited and mixed data regarding the efficacy of vitamin D supplementation on body composition and ...

Exploring the Impact of Obesity, Type 2 Diabetes Mellitus, Nerve Growth Factor, and Exercise on Skeletal Muscle 

Jun, Lauren (2024-05-01)  ETD File Embargoed
Skeletal muscle is the largest organ of the body with many essential functions. Recent studies have linked obesity and type 2 diabetes mellitus (T2DM) with skeletal muscle loss and dysfunction. The first objective of this ...

High Fat Sugar Diet Induces Skeletal Muscle Degeneration and the Beneficial Effect of Time Restricted Feeding 

Zhang, Yuxian (2020-05-13)  ETD File Embargoed
High fat sugar diet (HFS) is a high-energy diet and has been shown to lead to obesity and many related disorders. Obesity is a risk factor for a lot of diseases and previous studies have suggested that obesity is associated ...

Mediterranean Diet Adherence in the Southeast United States: Validation of a Field-Based Survey Instrument and the Impact of Nutrition Knowledge 

Bottcher, Mary (2016-07-29)
The Mediterranean diet (MD) has been shown to reduce chronic disease risk, and nutrition knowledge has been shown to correlate with diet choices. However, Mediterranean diet adherence in the southeast United States is ...

The Mediterranean diet in a university student population: a cross-sectional study on adherence and perceived knowledge, barriers, and benefits 

Yildiz, Serhat (2023-04-28)
The Dietary Guidelines for Americans recommend incorporating the Mediterranean diet (MD) into one's eating habits. Nevertheless, it is uncertain if university students have increased their adoption of this diet from 2018 ...

Molecular Mechanisms Regulating Hepatic Fetuin-A Expression 

Kothari, Vishal (2016-12-05)
Fetuin-A (Fet-A) is a hepatokine, known to inhibit insulin signaling and is associated with diabetes, cardiovascular outcomes and inflammation. Post-translational modification of fetuin-A at different glycosylation and ...

Neuroprotective effects of Resveratrol against oxidative stress and memory impairment in vivo and in vitro 

Rege, Shraddha (2016-06-13)
Resveratrol is a polyphenolic phytoalexin known to exert anti-diabetic, anti-inflammatory and neuroprotective effects. Various studies have reported a link between obese diabetic state and Alzheimer’s disease. The present ...

Nutrient Intake and Epigenetic Influences on Childhood Obesity: A Racial Perspective 

Patel, Priyadarshni (2023-12-01)  ETD File Embargoed
Obesity, a complex condition influenced by both genetic and environmental factors, poses a significant public health challenge. Despite extensive efforts in dietary, exercise, educational, surgical, and pharmacological ...

Pro-Nerve Growth Factor Induced RhoA Kinase Activation in PC12 Cells 

Sycheva, Marina (2017-07-27)
Alzheimer’s Disease (AD) is characterized by neurodegeneration and progressive decline in memory, cognition and independence. Nerve Growth Factor (NGF) is the neurotrophin responsible for mediating neuronal survival and ...

The Regulation of Release of Dipeptidyl Peptidase IV from Healthy and Diabetic Skeletal Muscle 

Neidert, Leslie (2017-07-25)
Dipeptidyl peptidase IV (DPP-IV) is a multifaceted enzyme that can be shed from skeletal muscle membrane via matrixmetalloproteinases (MMPs). Tissue inhibitors of MMPs (TIMP) within the extracellular matrix (ECM) modulate ...

The Role of Polyubiquitination in Nerve Growth Factor Signaling and its Alteration in Alzheimer’s Disease 

Zheng, Chen (2016-08-05)
Nerve growth factor (NGF) is a neurotrophin regulates survival and differentiation of neurons. To execute its antiapoptotic function, NGF binds to selective receptor TrkA and non-selective receptor p75NTR, leading to TrkA ...

The Role of Sugar-sweetened Water in the Progression of Nonalcoholic Fatty Liver Disease 

Luo, Yuwen (2016-12-08)
Nonalcoholic fatty liver disease (NAFLD), which ranges from simple steatosis (fatty liver) to nonalcoholic steatohepatitis (NASH), has become the most common chronic liver disease in both children and adults, paralleling ...

Sequestosome 1/p62 and TRAF6 are necessary for Akt ubiquitination, translocation and activation 

Carter, Andrea (2014-11-24)
Defects in protein-protein interactions of the insulin signaling pathway result in insulin resistance that precedes type 2 diabetes. The protein Akt is the primary modulator of cellular glucose uptake through the GLUT4 ...

Sequestosome 1/p62 and TRAF6 serve as a bridge to connect IRS-1 with Akt in insulin signaling 

Kumar, Sruthi (2013-04-08)
Abnormalities in the insulin-signaling pathway might result in insulin resistance, contributing to the development of type 2 diabetes. Previous studies have established the involvement of p62 in the insulin-signaling pathway ...

Toxicity Assessment of Clitocybe nuda as Natural Antimicrobials 

Qiao, Mingyu (2015-05-06)
Clitocybe nuda is an edible mushroom which shows promise to be developed as a novel natural food antimicrobial due to various antimicrobial components found in its fruit body as well as secondary metabolites in recent ...