Browsing Auburn Theses and Dissertations by Department "Interdepartmental Pharmacy"
Now showing items 41-60 of 65
Myocardial Ischemia/Reperfusion Injury and Cardioprotection: Novel Roles of Frataxin and Uridine Triphosphate
(2017-04-21)
Ischemia reperfusion (IR) injury in cardiac myocytes is well known to provoke membrane damage that is mediated by oxygen free radicals and that is associated with iron accumulation, energy dysregulation and opening of the ...
Nanoparticles-based Drug Delivery Systems for Resistant Cancer Treatment
(2021-11-29)
Many FDA-approved drugs have been repurposed as anticancer agents to fulfill the increasing demand for more effective anti-cancer drugs especially for drug-resistant cancers. Disulfiram (DSF) is an FDA-approved drug which ...
Novel mechanism of inhibition of the proteasome by Bruton’s Tyrosine Kinase inhibitors
(2023-12-12)
Bruton’s tyrosine kinase (BTK) inhibitor Ibrutinib has been shown to synergize in vitro with proteasome inhibitors (PIs) in reducing the viability of cells derived from B-cell malignancies. This synergy was also observed ...
Oleocanthal ameliorates metabolic and behavioral phenotypes, and pathology in a mouse model of Alzheimer’s disease
(2022-12-09)
The blood-brain barrier (BBB) healthiness is important to maintain brain homeostasis. The deposition of amyloid-β (Aβ) is one of Alzheimer’s disease’s (AD) causative pathways to induce brain neuronal loss. In addition, AD ...
P2Y2 Receptor Biased Signaling in Control of Vascular Inflammation
(2016-12-09)
Vascular inflammation plays a critical role in the pathogenesis of endotoxic shock and sepsis. Bacterial endotoxins like lipopolysaccharide (LPS) are biologically active substances that initiate the inflammatory response ...
The P2Y2 Receptor Control of Hyperglycemia-induced Insulin Resistance in Human Hepatocytes: A Unified Mechanism for Metformin
(2022-05-01)
According to the International Diabetes Federation, in 2021, 537 million adults were living with diabetes, and another 541 million adults were at increased risk of developing T2D (Facts & Figures, 2021.) Obesity, the most ...
Patients’ Preferences for Second-line Pharmacological Agents in Type 2 Diabetes
(2021-08-02)
The second-line antihyperglycemic agents (AHAs) for Type 2 Diabetes Mellitus (T2DM) have a wide variety of treatment attributes, including treatment benefits, side effects, and various treatment processes, such as dosage ...
Pharmacokinetic Modeling for In Vitro/In Vivo Transdermal Absorption
(2017-11-29)
The objective was to determine if a linear pharmacokinetic model could be developed to describe in vitro and in vivo transdermal absorption across normal and microporated skin. Such a model would enable formulators to ...
Potentially Inappropriate Medication Use and Access to Medication Management Services in Older Adults Living with Alzheimer's Disease and Related Dementia
(2023-05-03)
Background: Older adults living with Alzheimer's disease and related dementia (ADRD) have a higher risk of using potentially inappropriate medication (PIM) than those without ADRD. Even though Medication Therapy Management ...
Real-time Monitoring of Staphylococcus Aureus Biofilm Formation Under Flow Conditions in Microfluidic Chambers
(2020-07-21)
Staphylococcus aureus (S. aureus) causes most of life-threatening infections such as endocarditis, osteomyelitis and sepsis. Since biofilm development is often a key factor in the development of an infection of indwelling ...
Revalidating DNA Damage Inducible 1 Homolog II (DDI2) as a Novel Target for the Treatment of Cancer
(2023-05-04)
Cancer cells are under proteotoxic stress and are more sensitive to the perturbation of protein quality control pathways than normal cells. The proteasome is a critical component of the protein quality control machinery. ...
Riluzole prodrug alters hippocampal glutamatergic function: a mechanism for the amelioration of synaptic plasticity and memory deficits observed in a preclinical Alzheimer’s disease model
(2023-12-11)
Glutamate-mediated hippocampal hyperexcitability has been linked to the progression of Alzheimer’s disease (AD). Previous research suggests that drugs aimed at mediating glutamate dysregulation may also be useful AD ...
Role of Adipocyte P2Y2 Receptor in Adipogenesis and Insulin Resistance
(2022-05-03)
Objective -- It has been known that obesity and type 2 diabetes are associated with inflammation and insulin resistance and that adipose tissue contributes to insulin sensitivity and glucose homeostasis. Also, it was ...
Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease
(2022-04-14)
Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling ...
Role of the P2Y2 receptor/tissue factor axis in endotoxemia and atherothrombosis
(2021-12-06)
Inflammation and coagulation play a critical role in the pathogenesis of thrombosis. Biologically active substances initiate the inflammatory response in vascular endothelial cells (ECs) and immune cells, including ...
Safety and Effectiveness of Oral Anticoagulants in Patients with Atrial Fibrillation and Cancer
(2023-07-16)
Background: The use of oral anticoagulants (OACs) in patients with atrial fibrillation (AFib) and cancer remains suboptimal due to insufficient evidence in clinical guidelines. In this dissertation, our goals are to (1) ...
Selective PPARγ agonism attenuates pathologies and improves cognitive deficits in Alzheimer's disease
(2020-07-31)
The continuous increase association of Alzheimer's disease (AD) with the increasing aged population and mortality rate indicates an unmet medical need and the critical need for establishing novel molecular targets for ...
Staphylococcal and Streptococcal Biotechnology: Utilization of Bacterial Tools to Advance Preclinical Research and Healthcare
(2023-08-03)
Existing within microcosms of their own making, bacteria sculpt the surrounding environment by responding to the current climate or altering their habitat for protection and survival. The net effect of the bacterium’s ...
Strategies for Monitoring Pathologic Conditions and Treatment Efficacy in Murine Models
(2016-12-09)
On the surface, the pathologies of infectious disease and cancer appear fundamentally different; however, there exist several commonalities including pharmacological targets and resistance mechanisms, immune response, and ...
Studies on Expenditure, Prices, and Value of Disease-Modifying Antirheumatic Drugs
(2023-08-02)
Objectives: To determine the expenditure of rheumatoid arthritis (RA) and price changes, and to elicit the preference-based value of disease-modifying antirheumatic drugs (DMARDs).
Methods: First, Medical Expenditure ...