Browsing Auburn Theses and Dissertations by Department "Pharmacy"
Now showing items 1-20 of 29
Amylin and pramlintide modulate γ-secretase activity and APP processing in lipid rafts
(2019-06-24)
The misfolded amyloid-β (Aβ) peptide is generated in higher amounts in Alzheimer’s disease (AD), making this peptide a clinical hallmark for AD. A major site to produce Aβ is the lipid rafts, which are integral part of the ...
Application of Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) for Lipid-based Nanomedicine Development
(2017-04-25)
Secretory phospholipase A2 (sPLA2) are increased in various cancers. The lipid specificity and reactivity of sPLA2 and its ability to interact with PLA2 receptors (PLA2R) are potential targets for development of liposome ...
Assessment of Tofacitinib and Ruxolitinib and their Anti Inflammatory Effects on Myeloperoxidase
(2017-07-27)
Abstract
Myeloperoxidase (Mpo) is a heme-containing enzyme present in inflammation. Mpo catalyzes the production of hypochlorous acid (HCLO) by reacting with hydrogen peroxide (H2O2) and chloride (Cl-). Mpo together ...
The Blood-Brain Barrier as a Therapeutic Target for Alzheimer’s Disease and Related Disorders
(2019-06-10)
The blood-brain barrier (BBB) is a highly selective and protective membrane that preserves brain homeostasis and prevents the free entry of chemicals, toxins and drugs to the brain. The BBB barrier function is primarily ...
Chemokine Receptor CXCR7 in Vascular Biology and Disease
(2018-04-16)
Initially CXCR4 was thought to be the exclusive receptor for SDF-1. However, the discovery of a new SDF-1 receptor CXCR7, made the picture more complex. Whether CXCR7 is a “scavenger” receptor or not is still in debate. ...
Clinical Pharmacokinetic Analysis and Modeling of Tranexamic Acid in Dogs
(2018-05-30)
Tranexamic Acid (TXA) is an FDA approved drug for hemophilia patients undergoing dental extractions and women experiencing heavy bleeding during menstrual periods. It is also used to stop bleeding and decrease risk of ...
Cognitive Impairment and Its Consequences on Health among Breast Cancer Patients
(2018-07-24)
Objectives: The purpose of this study was to 1) examine the impact of preexisting cognitive impairment on survival and chronic medication adherence among older adults with breast cancer, 2) examine the association between ...
Comparative Effectiveness of Two Educational Health Mass Media Messages Different in Format
(2018-04-24)
Background: Meningitis B (MenB) is a rare but serious disease. Vaccination is an effective means to prevent MenB. It is recommended by the CDC that universities should consider all media delivery methods when aiming at ...
Disparities in the Appropriateness of Medication Use
(2018-11-27)
Background: Prior work has identified disparities in the quality and outcomes of health care across socioeconomic subgroups. Medication use may be subject to similar disparities.
Objectives: The objectives of this study ...
The Effects of Comorbid Asthma and Long-term Use of Corticosteroids on Clinical Outcomes of Prostate Cancer Patients
(2019-12-05)
Objectives: This study 1) examined burden of asthma among prostate cancer patients, asthma and prostate cancer treatment patterns, and factors associated with concurrent asthma, 2) assessed the associations between comorbid ...
Elucidating the dopaminergic neurotoxicity of kainic acid
(2020-08-21)
Dopamine is an essential catecholamine neurotransmitter in the central and peripheral nervous system. This monoaminergic neurotransmitters is required for the maintenance of several physiological functions (control of ...
The establishment of the Alabama Hereditary Cancer Cohort and genetic analysis
(2018-11-16)
Inherited genetic risk factors in known breast cancer (BC) susceptibility genes increase an individual’s overall lifetime risk of developing BC and are estimated to contribute towards approximately 35% of hereditary BC ...
Evaluating the dopaminergic neurotoxic effects of chemotherapeutics
(2018-04-30)
Chemotherapy-induced neurotoxicity is one of the most common contraindication seen in the cancer survivors. Thus chemotherapy-induced neurotoxicity can adversely affect the clinical management of these patients. Cancer ...
Examining the Effects of Message Framing on Medication Beliefs, Intentions to Take Medication, Medication Adherence, and Asthma Control among College Students
(2020-05-15)
Background: Asthma remains a burden to society with approximately $80 billion per year spent on asthma-related medical expenses in the United States. Inhaled corticosteroids (ICS), a mainstay medication for managing ...
Formulation of Phytochemicals in Lipid-Based Nanoparticles for Melanoma Treatment
(2019-04-25)
Melanoma is one of the most common and aggressive types of cancer with high mortality. Current treatment is ineffective in preventing relapse of cancer. It also suffers from serious systemic side effects because of the ...
GC-MS Studies on a Series of 1-pentylacylindoles: Regioisomeric Compounds Related to the Synthetic Cannabinoids.
(2016-07-12)
This thesis is primarily focused on analytical approaches to differentiate twenty isomeric
compounds related to designer drugs of the1-pentyl-acylindoles class. The compounds
investigated represent a series of synthetic ...
Identification of A New Pharmacological Modulator for P2Y2 Receptor Activity
(2018-04-23)
P2Y2 is a G-protein-coupled membrane receptor activated by ATP or UTP nucleotides. They play major roles in cellular physiology in different aspects including inflammatory responses and apoptosis. Therefore, P2Y2 receptor ...
Investigate the Effects of Designer Drugs on Amyloid Beta
(2020-07-15)
Designer drugs are structurally novel compounds that can exhibit several pharmacodynamic effects. The diverse pharmacodynamic effects of designer drugs are due to their significant interaction with the major drug targets ...
LC-MS based characterization of Mycobacterium tuberculosis shikimate kinase inhibitors containing oxadiazole-amide and aminobenzothiazole rings
(2016-07-26)
The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has increased the demand for the discovery of new antitubercular drugs. The shikimate pathway is essential ...
Nanoparticle and Gel Based Formulations for Enhanced Drug Delivery
(2017-11-28)
Nanogel and hydrogel formulations have shown promising advantages for topical and trans-mucosal routes of administration. The nanoparticle drug within the gel matrix showed significant enhancement in the permeation of drugs ...