Browsing Auburn University Graduate School by Department "Interdepartmental Pharmacy"
Now showing items 21-40 of 80
Drug Delivery Devices for Cancer and Posterior Eye
(2019-11-22)
Skin cancer is by far the most common of all cancers. Among all types of skin cancer, malignant melanoma causes most of the deaths. Likewise, breast cancer is the most common cancer in women after skin cancer and the second ...
Effect of Extended Exposure Topotecan on Drug Resistance Using a Novel 3D Spheroidal Model of Castrate-Resistant Prostate Cancer
(2023-04-24)
Cancer consistently commands the highest number of therapeutic drug approvals each year, however, this has yet to yield significant clinical benefits for metastatic disease. Instead, most drugs are likely to increase ...
Effectiveness, Safety, and Cost-Effectiveness of Immune Checkpoint Inhibitors for Metastatic Non-Small Cell Lung Cancer: Leveraging Real-World Evidence
(2025-08-06)
Objective: The purpose of this doctoral dissertation project was to 1) compare the effectiveness of first-line individual immune checkpoint inhibitor (ICI) agents and ICI in combination with chemotherapy (ICI-Chemotherapy) ...
Effects of Piperazine Derivatives on Hippocampal and Dopaminergic Neurotransmission
(2019-10-08)
Designer Drugs are a group of psychoactive substances synthesized from chemicals to emulate the pharmacodynamic and pharmacokinetic actions of widely used substances of abuse. A minor modification of the chemical structure ...
Elucidate the Neuro-Pharmacodynamic Actions of 3-Hydroxypterostilbene
(2022-11-29)
Pterostilbene (dimethyl ether analog of resveratrol) is a metabolically stable natural bioactive and has exhibited substantial pharmacological activities. 3-Hydroxypterostilbene is a natural pterostilbene analog and an ...
Elucidating the Neuroprotective Mechanisms of Tetrahydrocurcumin: A Key Curcumin Metabolite
(2026-04-13)
Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive “specific” neuronal loss at an “explicit” anatomical site in the brain driven by oxidative stress, mitochondrial ...
Elucidation of Cognitive Deficits Associated with Doxorubicin Treatment and Ameliorating Effects of Phenyl-2-Amino-Ethyl Selenide (PAESe)
(2017-04-25)
A growing body of evidence suggests that acute and chronic cognitive impairments are a common side-effect of chemotherapy. In fact, chemotherapy induced cognitive deficits or “chemobrain” are known to occur in up to 75% ...
Elucidation of the mechanism of learning and memory deficits in adolescent offspring due to prenatal cannabinoid exposure
(2020-07-21)
Cannabis is now one of the most commonly used illicit substances among pregnant and lactating women. This is particularly concerning given that developmental exposure to cannabinoids has been demonstrated to induce enduring ...
Empowering Community Pharmacists to Prevent Opioid Overdose Deaths: A Mixed Methods Study Exploring Implementation of Community Pharmacy-Based Naloxone Services
(2019-07-23)
Background and Significance: Given the rising problem of prescription drug abuse and high number of opioid-related deaths annually in the United States, mechanisms to distribute naloxone are sorely needed. Community ...
Endothelium5-HT3A receptor as a function of Age, ApoE, and ADRD pathology
(2026-04-20)
Alzheimer’s disease (AD) is the most common type of dementia, which is clinically characterized by cognitive and memory impairment. One of the major hallmarks of AD is the blood-brain barrier (BBB) dysfunction. The BBB is ...
ERBB4 is a Driver of BRAF WT Melanomas
(2023-04-28)
Approximately 50% of metastatic melanomas harbor a BRAF V600 mutation which causes elevated RAF/MEK/ERK pathway signaling. These tumors are treated using a combination of a BRAF and MEK inhibitor which targets the canonical ...
Establishment and optimization of the LC-MS-based strategy for screening of passively absorbed açaí and maca constituents for CYP3A4 inhibition
(2017-07-27)
The escalation of cancer morbidity and mortality has increased the use of botanical dietary supplements among cancer patients undergoing chemotherapy. Euterpe oleracea Mart. (açaí) berry and Lepidium meyenii Walpers (maca) ...
Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling
(2020-05-14)
In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...
Examining the Effects of Text Message and Competition-Based Interventions on Physical Activity, Self-Efficacy, Self-Regulation, Social Support, Incentive Motivation, and Mental Well-being among University Students
(2023-08-02)
Background: Compelling evidence highlights the importance of physical activity and its numerous benefits for both physical and mental well-being. However, physical activity levels remain low, particularly among university ...
Formulation of Water Insoluble Drugs for Ocular Delivery
(2018-07-24)
Cyclodextrins are unique cyclic molecules with a hydrophobic interior and hydrophilic exterior that can be used to solubilize, stabilize and enhance targetability of the encapsulated molecules. Chapter 1 will discuss uses ...
Geographical Access, Implementation Experience, and Patient Perception of Genetic Testing in the United States
(2022-06-29)
Backgrounds: Genetic testing is thriving, and its impact on human lives is enormous. However, the slow uptake of genetic testing into routine clinical practice indicates that much remains to be explored with regards to ...
Hormonal regulation for the prevention of cognitive decline of Alzheimer’s disease
(2025-04-23)
Alzheimer’s disease (AD) is the most common form of dementia, with its two pathological hallmarks being the abnormal accumulation of amyloid beta (Aβ) and the hyperphosphorylation of tau, leading to neuronal degradation. ...
Illuminating the Neurotoxic Effects of TFMPP derivatives in N27 Rat Dopaminergic Neuronal Cells through Oxidative Stress and Mitochondrial Dysfunction
(2017-05-03)
The use of designer drugs in the United States have increased tremendously. Designer drugs
are highly dangerous and most importantly the abusers don't have a clue with regard to what they
are getting. Thus, it is currently ...
Immunoproteasome Inhibitors for the Treatment of MLL-AF4 ALL
(2024-02-15)
Acute lymphoblastic leukemia, ALL, is a cancer of the blood or bone marrow that develops from the uncontrolled proliferation of lymphocytes. One subtype of ALL is caused by a translocation involving the MLL gene, or mixed ...
Impact of the COVID-19 Pandemic on Pharmacy-based Immunization in Rural USA: a cross-sectional study of community pharmacists from five Southeastern States
(2021-11-29)
Background: Immunization rates for seasonal and non-seasonal vaccines dropped during the COVID-19 pandemic. Little is known about the extent to which community pharmacies continue to serve as immunization sites during the ...