Browsing Auburn University Graduate School by Department "Interdepartmental Pharmacy"
Now showing items 1-20 of 71
Adiponectin alters hippocampal synaptic function: a mechanism for amelioration of synaptic deficits in a mouse model of Alzheimer’s disease
(2019-12-06)
The hormone adiponectin, the most abundant adipokine, is an important regulator of metabolic function, and recent evidence suggests that adiponectin plays an essential role in the cross-talk between adipose tissue and brain ...
Advancing Cancer Treatment: Nano-Based Therapy and Innovative Evaluation Platform
(2024-04-29)
Cancer continues to be a predominant cause of mortality despite extensive research efforts. The intricate microenvironment surrounding cancer poses formidable challenges for effective treatment strategies. In response to ...
Application of 3D Printing in Personalized Drug Delivery Devices and Dosage Forms
(2023-11-03)
The evolution of 3D Printing (3DP) and its applications in various disciplines, including healthcare, in the past few years has been exemplary. The gradual shift from the conventional “one size fits all” concept to ...
Assessing Barriers and Increasing Use of Immunization Information Systems in Pharmacies: A Randomized Controlled Trial
(2019-09-19)
The role of pharmacists as immunization providers is increasingly common. However, as the number of providers administering vaccines increases, there is a concern of fragmented immunization records in state and regional ...
Assessment of Risk and Risk Factors of Fluoropyrimidine-induced Cardiotoxicity among Colorectal Cancer Survivors Using a Mixed-Methods Approach
(2021-06-18)
Although new cancer treatment therapy has been increasingly developed, fluoropyrimidines, such as 5-fluorouracil (5-FU) and capecitabine, are widely used alone or in combination regimens as chemotherapy for the treatment ...
Chemical characterization and biological assessment of Euterpe oleracea Mart. (açaí) for in vitro botanical-drug interactions with anticancer drugs
(2024-04-29)
Cancer is the leading cause of death worldwide, with an estimated 19.3 million new cases in 2020 and almost 10 million cancer deaths. Botanical dietary supplements (BDS) are consumed more by cancer patients than otherwise ...
A comparative genomics approach to identify novel inherited cancer risk variants in dogs and humans
(2021-07-19)
Dogs provide a very special and unique opportunity for novel discovery in inherited disease studies. Through breeding practices to aid in the development of specific breeds, dog breeds are a very homogenous population, ...
Comparative Utilization, Effectiveness, and Safety of Denosumab versus Zoledronic Acid in Patients with Metastatic Lung, Breast, and Prostate Cancer
(2024-07-27)
Background: Metastatic lung, breast, and prostate cancer patients (MLBPC) experience several skeletal related events (SREs), which significantly decrease survival and quality of life. Denosumab (DS) and Zoledronic acid ...
Comprehensive Safety Evaluation of Proton Pump Inhibitors
(2021-02-12)
Objective: This study1) examined trends in proton pump inhibitor (PPI) use and associated healthcare spending among the U.S. population, 2) identified adverse outcomes associated with PPI use, and 3) conducted a systematic ...
Computational Modeling, Design and Synthesis of Selective Cannabinoid Receptor 2 (CB2) Agonists
(2021-12-08)
Synthetic cannabinoids that are synthesized and used recreationally are a world-wide health problem. They are synthesized in order to mimic the euphoric effects similar to THC, but due to the higher affinity at the cannabinoid ...
CRISPR/Cas9-mediated Gene Editing to Assess the Role of CXCR7 in Cervical Cancer
(2021-11-29)
Objective: Chemokine receptors and their corresponding chemokine ligands play a significant role in tumor cell survival and proliferation. CXCR7 is a receptor often overexpressed in different cancers including cervical ...
CYP3A4 inhibition and induction studies coupled to parallel artificial membrane permeability assay (PAMPA) for improved prediction of in-vitro botanical-drug interactions
(2019-07-10)
The consumption of botanical dietary supplements (BDS) is a common practice among the US population. However, the potential for botanical-drug interactions exists, and their mechanisms have not been thoroughly studied. ...
Deep tissue imaging of B16 melanoma in mice by Multispectral Optoacoustic Tomography
(2022-06-23)
Melanoma is an aggressive type of skin cancer that can metastasize to draining lymph nodes and distant organs. Early detection of melanoma holds the promise of improved patient outcomes by enabling earlier surgical ...
Design and Development of Novel LXRβ Agonists for Alzheimer’s Disease
(2025-08-05)
A progressive neurodegenerative disease, Alzheimer's disease (AD) is identified by the buildup of insoluble protein aggregates, such as Tau and amyloid beta. Amyloid beta (Aβ) and Tau protein processing genetic predispositions ...
Design and development of novel selective LXR/PPAR dual agonists for Alzheimer’s Disease.
(2024-08-02)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of insoluble protein aggregates, i.e., amyloid beta and Tau. Genetic predispositions in amyloid beta (A) and Tau protein ...
Determine the Anticancer Activity and Mechanism of Overcoming Drug Resistance by Cu(DDC)2 NPs in Prostate Cancers
(2021-07-14)
Copper diethyldithiocarbamate [Cu(DDC)2] complex formed by disulfiram (DSF) and copper ions is a promising therapeutic agent for cancer treatment. However, the poor aqueous solubility of Cu(DDC)2 limited its clinical ...
Development of micelle delivery systems for cancer therapy
(2023-12-08)
Polymeric micelles have been investigated as nanomedicines for cancer treatment. They can target specific tissues, prolong circulation, and reduce side effects. These features make them a promising delivery system for ...
Drug Delivery Devices for Cancer and Posterior Eye
(2019-11-22)
Skin cancer is by far the most common of all cancers. Among all types of skin cancer, malignant melanoma causes most of the deaths. Likewise, breast cancer is the most common cancer in women after skin cancer and the second ...
Effect of Extended Exposure Topotecan on Drug Resistance Using a Novel 3D Spheroidal Model of Castrate-Resistant Prostate Cancer
(2023-04-24)
Cancer consistently commands the highest number of therapeutic drug approvals each year, however, this has yet to yield significant clinical benefits for metastatic disease. Instead, most drugs are likely to increase ...
Effectiveness, Safety, and Cost-Effectiveness of Immune Checkpoint Inhibitors for Metastatic Non-Small Cell Lung Cancer: Leveraging Real-World Evidence
(2025-08-06)
Objective: The purpose of this doctoral dissertation project was to 1) compare the effectiveness of first-line individual immune checkpoint inhibitor (ICI) agents and ICI in combination with chemotherapy (ICI-Chemotherapy) ...