Browsing Auburn Theses and Dissertations by Department "General Veterinary Medicine"
Now showing items 61-80 of 98
Mammaglobin-A: A Potential Immunotherapy Target for Canine Mammary Cancer
(2020-12-01)
Canine mammary tumors are the most common neoplasms in unspayed, female canine patients. Currently, there is no universally accepted standard-of-care for chemotherapy or radiation after surgery. Therapies aimed at ...
Methods for Isolating Canine Mast Cell Progenitors, Melanocytes, and Keratinocytes
(2020-04-21)
One of the most difficult aspects of employing precision medicine in the treatment of cancer is determining the best targets to treat within the tumor. A trademark of cancers is that, while two patients may present similar ...
microRNA as Predictive Biomarkers of Canine Mammary Tumors
(2019-07-18)
Canine mammary tumors (CMT) are one of the most common forms of cancer in intact female dogs. CMTs share clinical, epidemiologic, and genetic features with women with breast cancer (BC). BC and CMT cells have altered ...
Minimally invasive routes of AAV administration to treat GM1 gangliosidosis
(2020-04-17)
GM1 gangliosidosis is a lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (βgal), which results in the accumulation of GM1 ganglioside and fatal neurodegeneration. In the human type II (late ...
Modulation of Human PXR by Novel KRAS-G12C Inhibitors: Implications in Cancer Therapy
(2023-08-01)
The nuclear receptor human pregnane xenobiotic receptor (hPXR) is a transcription factor responsible for the regulation of key drug metabolism enzymes (DMEs) and drug efflux pumps (DEPs), including cytochrome p450 3A4 ...
Molecular and serological diagnosis of Dirofilaria immitis in companion animals, USA
(2024-04-12)
Heartworm Disease (HWD) is caused by the nematode Dirofilaria immitis; a zoonotic infectious agent that affects companion animals and is transmitted by mosquito vectors. The diagnosis of HWD can be achieved by the combination ...
Molecular Biology and Epidemiology of Human and Feline Coronaviruses
(2022-12-05)
Coronaviruses (CoVs) are RNA viruses belonging to the Coronaviridae family and known to infect various hosts such as pigs (porcine epidemic diarrhea virus), cats (feline infectious peritonitis virus), birds (avian coronavirus), ...
Multi-dose misoprostol pharmacokinetics and its effect on the fecal microbiome in healthy, adult horses
(2023-07-17)
Misoprostol, a synthetic prostaglandin E1 (PGE1) analogue, is administered to treat glandular gastric ulcers in horses and may possess anti-inflammatory properties. However, misoprostol’s multi-dose pharmacokinetics and ...
Multilevel Targeting of Canine Adenovirus Type 2 (CAV2) to Expand Oncolytic Virotherapy in Canine Tumors
(2020-04-06)
Oncolytic virotherapy is a promising therapeutic approach designed to selectively eradicate cancer cells but to spare normal cells. Oncolytic adenoviruses (Ad) are an outstanding and common vehicle for efficient cancer ...
Myelin Deficits and Intravenous Gene Therapy in Feline Sandhoff Disease
(2021-07-27)
Sandhoff Disease (SD) is a neurodegenerative lysosomal storage disease (LSD) that results in the death of children before 4 years of age. Because there are no FDA-approved therapies available, current treatment strategies ...
Navigating the Complexities of Disease Prevention, Alternative Treatments, and Multi-Drug Resistant Rhodococcus equi Mitigation Strategies
(2023-07-28)
The opportunistic pathogen, Rhodococcus equi, is a robust soil saprophyte present in the environment of horse-breeding farms and an important cause of pulmonary disease in foals at endemic farms. As an effort to prevent ...
Neuroprotective effects of carnitinoid antioxidants in rodent models of mitochondrial dysfunction
(2016-07-27)
The pathological effects of mitochondrial dysfunction result from both oxidative damage and bioenergetic deficiency, and are more severe in cells and tissues with high metabolic energy demands such as neurons, skeletal ...
Novel Analgesics and the Impact of Route of Administration in the Horse
(2019-12-05)
primary goal of this dissertation was to describe the disposition of novel analgesics and the impact of their administration on the equine patient. In order to support this aim, a novel, non-septic, transient model of ...
Novel Approaches to the Molecular Characterization of Primary Canine Osteosarcoma
(2023-07-24)
Osteosarcoma (OSA) is an aggressive malignant bone tumor that often affects pediatric humans as well as dogs. Canine OSA shares many similarities with the human condition, including clinical presentation and molecular ...
Novel Infectious Bronchitis Virus Vaccines and Immune Responses
(2019-11-25)
Infectious bronchitis virus (IBV) occurs as multiple serotypes and genotypes worldwide. In the United States IBV belonging to the Arkansas (Ark) Delmarva Poultry Industry (DPI) genotype is the most frequently isolated ...
Orally administered torsemide in horses: pharmacokinetic and pharmacodynamic studies
(2018-08-02)
Diuretic therapy is the mainstay for management of congestive heart failure in horses. Loop-diuretic medications in horses have been restricted to injectable medications because currently, no data support the use of ...
Orthobiologic use for equine joint disease
(2020-11-23)
Osteoarthritis (OA) is the leading cause of musculoskeletal disability in people and
Horses. There is a critical need for better understanding of new therapeutics and their effects on the disease. Orthobiologics are ...
Phage-GnRH Constructs for Population Control of Feral Animals: Evaluation in Cats
(2018-11-15)
The overpopulation of cats is a problem in the United States and worldwide due to public health concerns and their role as a predator of wildlife species. The focus of this research is the development of anti-fertility ...
Pharmacodynamic Effects of Pioglitazone on High Molecular Weight Adiponectin Concentrations and Insulin Response after Oral Sugar in Equids
(2019-07-10)
Chronic insulin dysregulation is challenging to manage with pharmaceuticals in horses. Pioglitazone improves insulin sensitivity in humans, and the pharmacokinetics of pioglitazone have been evaluated in horses. The ...
Pharmacokinetics of pimobendan and its metabolite o-desmethyl-pimobendan following rectal administration to healthy dogs
(2020-06-29)
Pimobendan, a benzimidazole-pyridazinone derivative, is an inodilator that is used for the treatment of congestive heart failure in dogs. Pharmacokinetics of pimobendan and its active metabolite o-desmethyl pimobendan ...