Browsing Auburn Theses and Dissertations by Department "General Veterinary Medicine"
Now showing items 81-98 of 98
Pharmacological characterization and functional rescue of the giant panda and human melanocortin-4 receptors
(2017-07-25)
The melanocortin-4 receptor (MC4R) is a member of family A rhodopsin-like G protein-coupled receptors. It is well established that MC4R is critically involved in regulating food intake and energy expenditure in mammals. ...
Pharmacological characterization of fish melanocortin-4 and melanocortin-5 receptors
(2021-07-12)
The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. The melanocortin-5 receptor (MC5R) has been implicated in the regulation of exocrine gland secretion, ...
Pharmacological regulation of melanocortin-3 and -4 receptors by melanocortin-2 receptor accessory protein 1 or 2
(2022-07-25)
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 ...
Prevention and Pathogenesis of Avian Infectious Bronchitis: The Role of Infectious Bronchitis Virus Spike Proteins in Cell Attachment and Protective Immunity
(2017-12-01)
Infectious bronchitis virus (IBV) evolves by genetic diversity and selection resulting in continuous emergence of new virus phenotypes. Spike (S) protein is responsible for virus entry. The S1 subunit of the S glycoprotein ...
Protective Efficacy of a Recombinant Newcastle Disease Virus against Infectious Bronchitis
(2021-07-13)
A previous study has reported that Newcastle disease virus (NDV) recombinant LaSota strain (rLS) expressing infectious bronchitis virus (IBV) Arkansas-type (Ark) trimeric spike ectodomain (Se) (rLS/ArkSe) provides suboptimal ...
Resistance to colistin and carbapenem among Enterobacteriaceae recovered from human and animal sources is associated with multiple genetic mechanisms
(2021-05-14)
Colistin and carbapenem and are important last-resort antimicrobials to treat infections caused by multidrug-resistant Gram-negative bacteria. Understanding the genetic mechanisms conferring resistance to colistin and ...
The role of hormones in the development of the adrenal gland
(2023-08-02)
The adrenal cortex, a crucial endocrine gland, is comprised of three distinct regions: the zona glomerulosa, zona fasciculata, and zona reticularis (referred to as the X-zone in mice). This organ plays a critical role in ...
The role of hormones in the development of the adrenal gland
(2023-08-02)
The adrenal cortex, a crucial endocrine gland, is comprised of three distinct regions: the zona glomerulosa, zona fasciculata, and zona reticularis (referred to as the X-zone in mice). This organ plays a critical role in ...
Role of IFN-λ in Herpes Simplex Virus-1-induced corneal Immunopathology
(2024-04-30)
The Herpes simplex virus (HSV) is a highly successful pathogen in the Herpesviridae family, consisting of eight enveloped human herpesviruses. These double-stranded DNA viruses with similar morphology can reactivate latent ...
Role of IL-27 in HSV-1-induced Herpetic Stromal Keratitis
(2024-04-12)
Herpes Stromal Keratitis (HSK) results from ocular infection with Herpes simplex virus-1 (HSV-1) and is one of the leading causes of infectious blindness. After primary lytic infection in the facial region, the virus ...
Role of Intrauterine Bovine Viral Diarrhea Virus in Modulating Host Gene Expression at the Maternal-Fetal Interface
(2017-04-25)
Bovine viral diarrhea virus (BVDV) is a member of the genus Pestivirus within the family Flaviviridae. Infections with BVDV have a substantial economic impact on beef and dairy producers in the United States and worldwide. ...
The role of zinc nanoparticles in the initial events of olfaction, their characterization, preservation, and microenvironmental influence.
(2018-04-24)
Olfactory responses are intensely enhanced with the addition of endogenous and engineered primarily-elemental small zinc nanoparticles (ZnNPs). The endogenous ZnNPs have been found as proteon nucleating centers (PNCs) ...
Salmonella Bacteriophage-Resistance Genomic Analysis, Computational Approaches of Environmental Data, and Chicken Embryo Lethality Assay
(2024-04-29)
This dissertation is a coalescence of three individual projects with Salmonella being the only area that the projects have in common. Bacteriophage (phage) treatment for the reduction of multiple drug-resistant Salmonella ...
Structure-function relationship of human melanocortin-4 receptor and characterization of fish neural melanocortin receptors
(2019-07-19)
The neural melanocortin receptors, including melanocortin-3 and -4 receptors (MC3R and MC4R), are two important factors in regulation of energy homeostasis. MC3R primarily regulates feed efficiency and nutrient partitioning, ...
A Study of a Bacteriophage-Resistant Salmonella Mutant and Factors Influencing Prevalence of Salmonella in a Multi-Species Animal Facility
(2016-12-08)
Bacteriophage (phage) treatment for the reduction of multiple drug resistant Salmonella Newport in dairy calves is being examined in our lab from a clinical disease and food safety perspective. An unintended consequence ...
Sustained-Release Voriconazole-Thermogel for Subconjunctival Injection in Horses: Ocular Toxicity and in-vivo Studies
(2017-07-31)
Subconjunctival (SC) injection of a thermosensitive voriconazole-hydrogel poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) may allow for sustained delivery of voriconazole to the ...
Taxonomic Profiling of the Lumen and Epimural Surface of the Duodenum, Rumen and Ileum Using a Cannulated Bovine Model
(2021-04-16)
The gut microbiome provides important metabolic functions for the host animal. Bacterial dysbiosis as a result of bacterial, viral, and parasitic gastrointestinal infections can adversely affect the metabolism, productivity, ...
Use of Accelerometers to Characterize Behavior in Beef Cattle During Health and Subclinical Disease
(2017-11-30)
The acute phase response (APR) represents a protective, coordinated response of the host with the aim of eliminating the inciting stimuli and re-establishing homeostasis. Produced by activated immune cells, proinflammatory ...