This Is AuburnElectronic Theses and Dissertations

Browsing Auburn Theses and Dissertations by Department "Interdepartmental Pharmacy"

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Adiponectin alters hippocampal synaptic function: a mechanism for amelioration of synaptic deficits in a mouse model of Alzheimer’s disease 

Bloemer, Jenna (2019-12-06)
The hormone adiponectin, the most abundant adipokine, is an important regulator of metabolic function, and recent evidence suggests that adiponectin plays an essential role in the cross-talk between adipose tissue and brain ...

Assessing Barriers and Increasing Use of Immunization Information Systems in Pharmacies: A Randomized Controlled Trial 

Hastings, Tessa (2019-09-19)
The role of pharmacists as immunization providers is increasingly common. However, as the number of providers administering vaccines increases, there is a concern of fragmented immunization records in state and regional ...

Assessment of Risk and Risk Factors of Fluoropyrimidine-induced Cardiotoxicity among Colorectal Cancer Survivors Using a Mixed-Methods Approach 

Li, Chao (2021-06-18)  ETD File Embargoed
Although new cancer treatment therapy has been increasingly developed, fluoropyrimidines, such as 5-fluorouracil (5-FU) and capecitabine, are widely used alone or in combination regimens as chemotherapy for the treatment ...

A comparative genomics approach to identify novel inherited cancer risk variants in dogs and humans 

Huskey, Anna Laureen Watkins (2021-07-19)  ETD File Embargoed
Dogs provide a very special and unique opportunity for novel discovery in inherited disease studies. Through breeding practices to aid in the development of specific breeds, dog breeds are a very homogenous population, ...

Comprehensive Safety Evaluation of Proton Pump Inhibitors 

Mishuk, Ahmed Ullah (2021-02-12)  ETD File Embargoed
Objective: This study1) examined trends in proton pump inhibitor (PPI) use and associated healthcare spending among the U.S. population, 2) identified adverse outcomes associated with PPI use, and 3) conducted a systematic ...

Computational Modeling, Design and Synthesis of Selective Cannabinoid Receptor 2 (CB2) Agonists 

Neel, Logan (2021-12-08)
Synthetic cannabinoids that are synthesized and used recreationally are a world-wide health problem. They are synthesized in order to mimic the euphoric effects similar to THC, but due to the higher affinity at the cannabinoid ...

CRISPR/Cas9-mediated Gene Editing to Assess the Role of CXCR7 in Cervical Cancer 

Alqahtani, Saud (2021-11-29)  ETD File Embargoed
Objective: Chemokine receptors and their corresponding chemokine ligands play a significant role in tumor cell survival and proliferation. CXCR7 is a receptor often overexpressed in different cancers including cervical ...

CYP3A4 inhibition and induction studies coupled to parallel artificial membrane permeability assay (PAMPA) for improved prediction of in-vitro botanical-drug interactions 

Zhang, Yilue (2019-07-10)
The consumption of botanical dietary supplements (BDS) is a common practice among the US population. However, the potential for botanical-drug interactions exists, and their mechanisms have not been thoroughly studied. ...

Deep tissue imaging of B16 melanoma in mice by Multispectral Optoacoustic Tomography 

Bahauddin, Ammar (2022-06-23)  ETD File Embargoed
Melanoma is an aggressive type of skin cancer that can metastasize to draining lymph nodes and distant organs. Early detection of melanoma holds the promise of improved patient outcomes by enabling earlier surgical ...

Determine the Anticancer Activity and Mechanism of Overcoming Drug Resistance by Cu(DDC)2 NPs in Prostate Cancers 

Wang, Junwei (2021-07-14)  ETD File Embargoed
Copper diethyldithiocarbamate [Cu(DDC)2] complex formed by disulfiram (DSF) and copper ions is a promising therapeutic agent for cancer treatment. However, the poor aqueous solubility of Cu(DDC)2 limited its clinical ...

Drug Delivery Devices for Cancer and Posterior Eye 

Alrbyawi, Hamad (2019-11-22)  ETD File Embargoed
Skin cancer is by far the most common of all cancers. Among all types of skin cancer, malignant melanoma causes most of the deaths. Likewise, breast cancer is the most common cancer in women after skin cancer and the second ...

Effects of Piperazine Derivatives on Hippocampal and Dopaminergic Neurotransmission 

Majrashi, Mohammed (2019-10-08)  ETD File Embargoed
Designer Drugs are a group of psychoactive substances synthesized from chemicals to emulate the pharmacodynamic and pharmacokinetic actions of widely used substances of abuse. A minor modification of the chemical structure ...

Elucidation of Cognitive Deficits Associated with Doxorubicin Treatment and Ameliorating Effects of Phenyl-2-Amino-Ethyl Selenide (PAESe) 

Alhowail, Ahmad (2017-04-25)
A growing body of evidence suggests that acute and chronic cognitive impairments are a common side-effect of chemotherapy. In fact, chemotherapy induced cognitive deficits or “chemobrain” are known to occur in up to 75% ...

Elucidation of the mechanism of learning and memory deficits in adolescent offspring due to prenatal cannabinoid exposure 

Pinky, Priyanka (2020-07-21)  ETD File Embargoed
Cannabis is now one of the most commonly used illicit substances among pregnant and lactating women. This is particularly concerning given that developmental exposure to cannabinoids has been demonstrated to induce enduring ...

Empowering Community Pharmacists to Prevent Opioid Overdose Deaths: A Mixed Methods Study Exploring Implementation of Community Pharmacy-Based Naloxone Services 

Hohmann, Lindsey (2019-07-23)
Background and Significance: Given the rising problem of prescription drug abuse and high number of opioid-related deaths annually in the United States, mechanisms to distribute naloxone are sorely needed. Community ...

Establishment and optimization of the LC-MS-based strategy for screening of passively absorbed açaí and maca constituents for CYP3A4 inhibition 

Rants'o, Thankhoe Abram (2017-07-27)
The escalation of cancer morbidity and mortality has increased the use of botanical dietary supplements among cancer patients undergoing chemotherapy. Euterpe oleracea Mart. (açaí) berry and Lepidium meyenii Walpers (maca) ...

Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling 

Darakjian, Lucy (2020-05-14)
In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...

Formulation of Water Insoluble Drugs for Ocular Delivery 

Shelley, Haley (2018-07-24)
Cyclodextrins are unique cyclic molecules with a hydrophobic interior and hydrophilic exterior that can be used to solubilize, stabilize and enhance targetability of the encapsulated molecules. Chapter 1 will discuss uses ...

Illuminating the Neurotoxic Effects of TFMPP derivatives in N27 Rat Dopaminergic Neuronal Cells through Oxidative Stress and Mitochondrial Dysfunction 

Majrashi, Mohammed (2017-05-03)
The use of designer drugs in the United States have increased tremendously. Designer drugs are highly dangerous and most importantly the abusers don't have a clue with regard to what they are getting. Thus, it is currently ...

Impact of the COVID-19 Pandemic on Pharmacy-based Immunization in Rural USA: a cross-sectional study of community pharmacists from five Southeastern States 

AlMahasis, Sura (2021-11-29)
Background: Immunization rates for seasonal and non-seasonal vaccines dropped during the COVID-19 pandemic. Little is known about the extent to which community pharmacies continue to serve as immunization sites during the ...