Browsing Auburn Theses and Dissertations by Department "Interdepartmental Pharmacy"
Now showing items 1-20 of 63
Adiponectin alters hippocampal synaptic function: a mechanism for amelioration of synaptic deficits in a mouse model of Alzheimer’s disease
(2019-12-06)
The hormone adiponectin, the most abundant adipokine, is an important regulator of metabolic function, and recent evidence suggests that adiponectin plays an essential role in the cross-talk between adipose tissue and brain ...
Application of 3D Printing in Personalized Drug Delivery Devices and Dosage Forms
(2023-11-03)
The evolution of 3D Printing (3DP) and its applications in various disciplines, including healthcare, in the past few years has been exemplary. The gradual shift from the conventional “one size fits all” concept to ...
Assessing Barriers and Increasing Use of Immunization Information Systems in Pharmacies: A Randomized Controlled Trial
(2019-09-19)
The role of pharmacists as immunization providers is increasingly common. However, as the number of providers administering vaccines increases, there is a concern of fragmented immunization records in state and regional ...
Assessment of Risk and Risk Factors of Fluoropyrimidine-induced Cardiotoxicity among Colorectal Cancer Survivors Using a Mixed-Methods Approach
(2021-06-18)
Although new cancer treatment therapy has been increasingly developed, fluoropyrimidines, such as 5-fluorouracil (5-FU) and capecitabine, are widely used alone or in combination regimens as chemotherapy for the treatment ...
A comparative genomics approach to identify novel inherited cancer risk variants in dogs and humans
(2021-07-19)
Dogs provide a very special and unique opportunity for novel discovery in inherited disease studies. Through breeding practices to aid in the development of specific breeds, dog breeds are a very homogenous population, ...
Comprehensive Safety Evaluation of Proton Pump Inhibitors
(2021-02-12)
Objective: This study1) examined trends in proton pump inhibitor (PPI) use and associated healthcare spending among the U.S. population, 2) identified adverse outcomes associated with PPI use, and 3) conducted a systematic ...
Computational Modeling, Design and Synthesis of Selective Cannabinoid Receptor 2 (CB2) Agonists
(2021-12-08)
Synthetic cannabinoids that are synthesized and used recreationally are a world-wide health problem. They are synthesized in order to mimic the euphoric effects similar to THC, but due to the higher affinity at the cannabinoid ...
CRISPR/Cas9-mediated Gene Editing to Assess the Role of CXCR7 in Cervical Cancer
(2021-11-29)
Objective: Chemokine receptors and their corresponding chemokine ligands play a significant role in tumor cell survival and proliferation. CXCR7 is a receptor often overexpressed in different cancers including cervical ...
CYP3A4 inhibition and induction studies coupled to parallel artificial membrane permeability assay (PAMPA) for improved prediction of in-vitro botanical-drug interactions
(2019-07-10)
The consumption of botanical dietary supplements (BDS) is a common practice among the US population. However, the potential for botanical-drug interactions exists, and their mechanisms have not been thoroughly studied. ...
Deep tissue imaging of B16 melanoma in mice by Multispectral Optoacoustic Tomography
(2022-06-23)
Melanoma is an aggressive type of skin cancer that can metastasize to draining lymph nodes and distant organs. Early detection of melanoma holds the promise of improved patient outcomes by enabling earlier surgical ...
Determine the Anticancer Activity and Mechanism of Overcoming Drug Resistance by Cu(DDC)2 NPs in Prostate Cancers
(2021-07-14)
Copper diethyldithiocarbamate [Cu(DDC)2] complex formed by disulfiram (DSF) and copper ions is a promising therapeutic agent for cancer treatment. However, the poor aqueous solubility of Cu(DDC)2 limited its clinical ...
Development of micelle delivery systems for cancer therapy
(2023-12-08)
Polymeric micelles have been investigated as nanomedicines for cancer treatment. They can target specific tissues, prolong circulation, and reduce side effects. These features make them a promising delivery system for ...
Drug Delivery Devices for Cancer and Posterior Eye
(2019-11-22)
Skin cancer is by far the most common of all cancers. Among all types of skin cancer, malignant melanoma causes most of the deaths. Likewise, breast cancer is the most common cancer in women after skin cancer and the second ...
Effect of Extended Exposure Topotecan on Drug Resistance Using a Novel 3D Spheroidal Model of Castrate-Resistant Prostate Cancer
(2023-04-24)
Cancer consistently commands the highest number of therapeutic drug approvals each year, however, this has yet to yield significant clinical benefits for metastatic disease. Instead, most drugs are likely to increase ...
Effects of Piperazine Derivatives on Hippocampal and Dopaminergic Neurotransmission
(2019-10-08)
Designer Drugs are a group of psychoactive substances synthesized from chemicals to emulate the pharmacodynamic and pharmacokinetic actions of widely used substances of abuse. A minor modification of the chemical structure ...
Elucidate the Neuro-Pharmacodynamic Actions of 3-Hydroxypterostilbene
(2022-11-29)
Pterostilbene (dimethyl ether analog of resveratrol) is a metabolically stable natural bioactive and has exhibited substantial pharmacological activities. 3-Hydroxypterostilbene is a natural pterostilbene analog and an ...
Elucidation of Cognitive Deficits Associated with Doxorubicin Treatment and Ameliorating Effects of Phenyl-2-Amino-Ethyl Selenide (PAESe)
(2017-04-25)
A growing body of evidence suggests that acute and chronic cognitive impairments are a common side-effect of chemotherapy. In fact, chemotherapy induced cognitive deficits or “chemobrain” are known to occur in up to 75% ...
Elucidation of the mechanism of learning and memory deficits in adolescent offspring due to prenatal cannabinoid exposure
(2020-07-21)
Cannabis is now one of the most commonly used illicit substances among pregnant and lactating women. This is particularly concerning given that developmental exposure to cannabinoids has been demonstrated to induce enduring ...
Empowering Community Pharmacists to Prevent Opioid Overdose Deaths: A Mixed Methods Study Exploring Implementation of Community Pharmacy-Based Naloxone Services
(2019-07-23)
Background and Significance: Given the rising problem of prescription drug abuse and high number of opioid-related deaths annually in the United States, mechanisms to distribute naloxone are sorely needed. Community ...
ERBB4 is a Driver of BRAF WT Melanomas
(2023-04-28)
Approximately 50% of metastatic melanomas harbor a BRAF V600 mutation which causes elevated RAF/MEK/ERK pathway signaling. These tumors are treated using a combination of a BRAF and MEK inhibitor which targets the canonical ...