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Browsing Auburn Theses and Dissertations by Author "Calderon, Angela"

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Applications of Mass spectrometry in natural product drug discovery for malaria: Targeting Plasmodium falciparum thioredoxin reductase 

Munigunti, Ranjith (2013-04-23)
Malaria is considered to be the dominant cause of death in low income countries especially in Africa. Malaria caused by Plasmodium falciparum is a most lethal form of the disease because of its rapid spread and the development ...

Catalase-Peroxidase: A Structure that Facilitates Electron Transfer, Protein-based Cofactor Formation, and Antibiotic Activation 

Barton, Callie (2022-12-09)
Catalase-peroxidase (KatG) is a heme-dependent enzyme that uses a single active for the degradation of H2O2 by two distinct mechanisms. One is a catalase mechanism where two equivalents of H2O2 are disproportionated with ...

Discovery and characterization of synthetic and natural compounds as inhibitors of shikimate kinase from Mycobacterium tuberculosis by LC-MS 

Simithy, Johayra (2014-12-10)
With the increasing emergence of drug-resistant tuberculosis (TB) and the complication by HIV co-infection, Mycobacterium tuberculosis (Mtb) remains a challenging target for drug discovery. The shikimate pathway, responsible ...

Investigating a novel protein-based cofactor: toward elucidating the catalase mechanism of Mycobacterium tuberculosis KatG 

Aziz, Tarfi (2022-12-07)
Catalase-peroxidases (KatGs) have been engineered by nature to exhibit dual functionalism, degrading H2O2 by catalase and peroxidase mechanisms. This serves to protect the organisms that carry it (primarily bacteria and ...

LC-MS based metabolite fingerprinting and profiling of a traditional Chinese medicine YANG XIN® formulation 

Almalki, Ahmad (2015-07-29)
For thousands of years, Traditional Chinese Medicine (TCM) has been used to treat or prevent various diseases, for this reason western countries have been attracted to and use TCM together with allopathic medicine. YANG ...

Mass Spectral, Infrared and Chromatographic Studies on Designer Drugs of the Piperazine Class 

Hafiz Abdel-Hay, Karim (2012-02-20)
The controlled drug 3,4-methylenedioxybenzylpiperazine (3,4-MDBP) has regioisomeric and isobaric substances of mass equivalence, which have similar analytical properties and thus the potential for misidentification. The ...

Synthesis, GC–MS, GC–MS/MS, GC–IR and chromatographic studies on cathinone derivatives related to methylenedioxypyrovalerone (MDPV) 

Abiedalla, Younis (2018-12-03)
This project will address issues of resolution and discriminatory capabilities for cathinone derivatives (regioisomeric and homologous groups) providing additional reliability and selectivity for forensic evidence and ...